Sandbox Reserved 1565

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== Structural Highlights and Structure-Function Relationships ==
== Structural Highlights and Structure-Function Relationships ==
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<scene name='82/823087/Impdh_secondary_structure/1'>IMPDH secondary structural features</scene>.
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<scene name='82/823087/Impdh_quaternary_structure/1'>IMPDH important quaternary structures</scene>.
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<scene name='82/823087/Impdh_space_filled/1'>IMPDH space filled view</scene>.
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<scene name='82/823087/Impdh_hydrophobicity/1'>IMPDH hydrophobicity view</scene>
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<scene name='82/823087/Impdh_ligand_view/1'>IMPDH ligand view
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</scene>.
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<scene name='82/823087/Impdh_triad/3'>IMPDH Triad</scene>.
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<scene name='82/823087/Impdh_triad_active_binding/1'>IMPDH active binding site</scene>.
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<scene name='82/823087/Impdh_charge/1'>IMPDH charge</scene>.
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<scene name='82/823087/Impdh_composition/1'>IMPDH composition</scene>.
== Energy Transformation ==
== Energy Transformation ==
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

Revision as of 03:46, 1 December 2019

This Sandbox is Reserved from Aug 26 through Dec 12, 2019 for use in the course CHEM 351 Biochemistry taught by Bonnie_Hall at the Grand View University, Des Moines, USA. This reservation includes Sandbox Reserved 1556 through Sandbox Reserved 1575.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

Inosine-5'-monophosphate dehydrogenase

Structure of the ternary complex of the IMPDH enzyme from Ashbya gossypii bound to the dinucleoside polyphosphate Ap5G and GDP

Drag the structure with the mouse to rotate

References

  1. ↑ Fernandez-Justel D, Pelaez R, Revuelta JL, Buey RM. The Bateman domain of IMP dehydrogenase is a binding target for dinucleoside polyphosphates. J Biol Chem. 2019 Aug 15. pii: AC119.010055. doi: 10.1074/jbc.AC119.010055. PMID:31416831 doi:http://dx.doi.org/10.1074/jbc.AC119.010055
  2. ↑ Fernandez-Justel D, Pelaez R, Revuelta JL, Buey RM. The Bateman domain of IMP dehydrogenase is a binding target for dinucleoside polyphosphates. J Biol Chem. 2019 Aug 15. pii: AC119.010055. doi: 10.1074/jbc.AC119.010055. PMID:31416831 doi:http://dx.doi.org/10.1074/jbc.AC119.010055
  3. ↑ Fernandez-Justel D, Pelaez R, Revuelta JL, Buey RM. The Bateman domain of IMP dehydrogenase is a binding target for dinucleoside polyphosphates. J Biol Chem. 2019 Aug 15. pii: AC119.010055. doi: 10.1074/jbc.AC119.010055. PMID:31416831 doi:http://dx.doi.org/10.1074/jbc.AC119.010055
  4. ↑ Hedstrom L, Liechti G, Goldberg JB, Gollapalli DR. The antibiotic potential of prokaryotic IMP dehydrogenase inhibitors. Curr Med Chem. 2011;18(13):1909-18. doi: 10.2174/092986711795590129. PMID:21517780 doi:http://dx.doi.org/10.2174/092986711795590129
  5. ↑ Bairagya HR, Mukhopadhyay BP. An insight to the dynamics of conserved water-mediated salt bridge interaction and interdomain recognition in hIMPDH isoforms. J Biomol Struct Dyn. 2012 Aug 28. PMID:22928911 doi:10.1080/07391102.2012.712458
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