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Protein kinase C
From Proteopedia
(Difference between revisions)
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</StructureSection> | </StructureSection> | ||
| - | ==3D structures of protein kinase C== | ||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *'''Conventional PKCs''' | ||
| - | |||
| - | *PKC-α | ||
| - | |||
| - | **[[2eli]] – hCPKC-α C1 domain – human – NMR<br /> | ||
| - | **[[4dnl]] - hCPKC-α C2 domain<br /> | ||
| - | **[[3iw4]], [[4ra4]] - hCPKC-α kinase domain + inhibitor<br /> | ||
| - | **[[1dsy]], [[3rdj]], [[3twy]], [[2nce]] – rCPKC-α C2 domain – rat | ||
| - | |||
| - | **[[4l1l]] - rCPKC-α C2 domain + ion<br /> | ||
| - | **[[5w4s]] - rCPKC- C2 domain + peptide<br /> | ||
| - | |||
| - | **[[3gpe]] - rCPKC-α C2 domain + Ca + PTDINS | ||
| - | |||
| - | *PKC-β | ||
| - | |||
| - | **[[1a25]] – rCPKC-β C2 domain<br /> | ||
| - | **[[3pfq]] - rCPKC-b II<br /> | ||
| - | |||
| - | *PKC-β2 | ||
| - | |||
| - | **[[2i0e]] - hCPKC-β2 catalytic domain | ||
| - | |||
| - | **[[3pfq]] - rCPKC-β2 (mutant) | ||
| - | |||
| - | *PKC-γ | ||
| - | |||
| - | **[[2uzp]] - hCPKC-γ C2 domain | ||
| - | |||
| - | **[[2e73]] - hCPKC-γ C1 domain - NMR | ||
| - | |||
| - | **[[1tbn]], [[1tbo]] - rCPKC-γ C2 domain – NMR<br /> | ||
| - | |||
| - | *'''Novel PKC''' | ||
| - | |||
| - | *PKC-δ | ||
| - | |||
| - | **[[1yrk]] – hNPKC-δ C2 domain + peptide | ||
| - | |||
| - | **[[2yuu]] - hNPKC-δ C1 domain - NMR | ||
| - | |||
| - | **[[2coa]] - hNPKC-δ PH domain – NMR<br /> | ||
| - | **[[1ptq]] – mNPKC-δ C2 domain – mouse<br /> | ||
| - | **[[3uej]] - mNPKC-δ C1B domain<br /> | ||
| - | **[[3uey]], [[3uff]], [[3ugd]], [[3ugi]], [[3ugl]] - mNPKC-δ C1B domain (mutant)<br /> | ||
| - | |||
| - | **[[1ptr]] - mNPKC-δ C2 domain + phorbol-acetate | ||
| - | |||
| - | **[[1bdy]] - rNPKC-δ C2 domain | ||
| - | |||
| - | *PKC-ε | ||
| - | |||
| - | **[[1gmi]] – rNPKC-ε C2 domain | ||
| - | |||
| - | *PKC-η | ||
| - | |||
| - | **[[2fk9]] – hNPKC-η C2 domain<br /> | ||
| - | **[[3txo]] - hNPKC-η kinase domain (mutant) + inhibitor<br /> | ||
| - | |||
| - | *PKC-θ | ||
| - | |||
| - | **[[4fkd]] – hNPKC-θ second Cys-rich regulatory domain<br /> | ||
| - | **[[2enj]] - hNPKC-θ C2 domain – NMR | ||
| - | |||
| - | **[[2enn]], [[2enz]] - hNPKC-θ C1 domain – NMR | ||
| - | |||
| - | **[[1xjd]] – hNPKC-θ + saurosporine | ||
| - | |||
| - | **[[2jed]], [[4q9z]], [[5f9e]], [[4ra5]] - hNPKC-θ kinase domain + inhibitor | ||
| - | |||
| - | *'''Atypical PKC''' | ||
| - | |||
| - | *PKC-ι; domains – PB1 16-99; kinase 249-588 | ||
| - | |||
| - | **[[1vd2]] – hAPKC-ι PB1 domain – NMR<br /> | ||
| - | **[[1wmh]] - hAPKC-ι PB1 domain + PAR6 alpha<br /> | ||
| - | **[[3a8w]], [[3a8x]], [[1zrz]] - hAPKC-ι kinase domain<br /> | ||
| - | **[[6ilz]] - hAPKC-ι kinase domain + inhibitor<br /> | ||
| - | **[[3zh8]] - hAPKC-ι kinase domain (mutant) + inhibitor<br /> | ||
| - | **[[1wmh]] - hAPKC-ι PB1 domain + PAR6 alpha<br /> | ||
| - | **[[4dc2]] - hAPKC-ι kinase domain + PAR3 peptide<br /> | ||
| - | **[[5lih]] - hAPKC-ι kinase domain + PKC-εζ peptide<br /> | ||
| - | |||
| - | *PKC-ν | ||
| - | |||
| - | **[[2d9z]] – hPKC-ν PH domain - NMR | ||
| - | |||
| - | *PKC-ζ | ||
| - | |||
| - | **[[4mjs]] - rPKC-ζ + sequestosome-1<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Idris I, Gray S, Donnelly R. Protein kinase C activation: isozyme-specific effects on metabolism and cardiovascular complications in diabetes. Diabetologia. 2001 Jun;44(6):659-73. PMID:11440359 doi:http://dx.doi.org/10.1007/s001250051675
- ↑ Koya D, King GL. Protein kinase C activation and the development of diabetic complications. Diabetes. 1998 Jun;47(6):859-66. PMID:9604860
- ↑ Koivunen J, Aaltonen V, Peltonen J. Protein kinase C (PKC) family in cancer progression. Cancer Lett. 2006 Apr 8;235(1):1-10. PMID:15907369 doi:http://dx.doi.org/10.1016/j.canlet.2005.03.033
- ↑ Guerrero-Valero M, Ferrer-Orta C, Querol-Audi J, Marin-Vicente C, Fita I, Gomez-Fernandez JC, Verdaguer N, Corbalan-Garcia S. Structural and mechanistic insights into the association of PKC{alpha}-C2 domain to PtdIns(4,5)P2. Proc Natl Acad Sci U S A. 2009 Apr 3. PMID:19346474
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