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Function(s) and Biological Relevance

Gives insights into substrate recognition and catalysis for the rational engineering of enzymes for chemoenzymatic synthesis and metabolic engineering.

Broader Implications

It is relevant because of the importance and utility of BIA compounds such as the use of metabolic engineering and synthetic biology approaches to reconstitute portions of the BIA biosynthetic pathways. However, most experiments have not provided substantial proof and explanations. In order to address this central problem in metabolic engineering, fundamental molecular, structural, and functional studies of BIA enzymes are needed. Overall, a deeper understanding of the enzyme structure and function will lead to an improved understanding of how BIA diversity is generated.

Structural highlights and structure-function relationships

Energy Transformation

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