1a0o

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[[Image:1a0o.gif|left|200px]]
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{{Seed}}
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[[Image:1a0o.png|left|200px]]
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{{STRUCTURE_1a0o| PDB=1a0o | SCENE= }}
{{STRUCTURE_1a0o| PDB=1a0o | SCENE= }}
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'''CHEY-BINDING DOMAIN OF CHEA IN COMPLEX WITH CHEY'''
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===CHEY-BINDING DOMAIN OF CHEA IN COMPLEX WITH CHEY===
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==Overview==
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Bacterial adaptation to the environment is accomplished through the coordinated activation of specific sensory receptors and signal processing proteins. Among the best characterized of these pathways are those which employ the two-component paradigm. In these systems, signal transmission is mediated by Mg(2+)-dependent phospho-relay reactions between histidine auto-kinases and phospho-accepting receiver domains in response-regulator proteins. Although this mechanism of activation is common to all response-regulators, detrimental cross-talk between different two-component pathways within the same cell is minimized through the use of specific recognition domains. Here, we report the crystal structure, at 2.95 A resolution, of the response regulator of bacterial chemotaxis, CheY, bound to the recognition domain from its cognate histidine kinase, CheA. The structure suggests that molecular recognition, in this low affinity complex (KD = 2 microM), may also contribute to the mechanism of CheY activation.
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The line below this paragraph, {{ABSTRACT_PUBMED_9437425}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9437425 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9437425}}
==About this Structure==
==About this Structure==
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[[Category: Signal transduction]]
[[Category: Signal transduction]]
[[Category: Two-component system]]
[[Category: Two-component system]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:38:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:44:26 2008''

Revision as of 12:44, 30 June 2008

Image:1a0o.png

Template:STRUCTURE 1a0o

CHEY-BINDING DOMAIN OF CHEA IN COMPLEX WITH CHEY

Template:ABSTRACT PUBMED 9437425

About this Structure

1A0O is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of the CheY-binding domain of histidine kinase CheA in complex with CheY., Welch M, Chinardet N, Mourey L, Birck C, Samama JP, Nat Struct Biol. 1998 Jan;5(1):25-9. PMID:9437425

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