6v2s
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of chromodomain of MPP8 in complex with inhibitor UNC3866== | |
| - | + | <StructureSection load='6v2s' size='340' side='right'caption='[[6v2s]], [[Resolution|resolution]] 1.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6v2s]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V2S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6V2S FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5R0:4-~{TERT}-BUTYLBENZOIC+ACID'>5R0</scene>, <scene name='pdbligand=5R5:METHYL+(2~{S})-2-AZANYL-3-OXIDANYL-PROPANOATE'>5R5</scene>, <scene name='pdbligand=ELY:N~6~,N~6~-DIETHYL-L-LYSINE'>ELY</scene></td></tr> |
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3r93|3r93]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6v2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v2s OCA], [http://pdbe.org/6v2s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6v2s RCSB], [http://www.ebi.ac.uk/pdbsum/6v2s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6v2s ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MPP8_HUMAN MPP8_HUMAN]] Involved in transcriptional regulation. Specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression.<ref>PMID:20871592</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Edwards, A M]] | ||
| + | [[Category: Liu, Y]] | ||
[[Category: Min, J]] | [[Category: Min, J]] | ||
| - | + | [[Category: Structural genomic]] | |
| - | + | ||
| - | + | ||
| - | [[Category: Structural | + | |
| - | + | ||
| - | + | ||
[[Category: Tempel, W]] | [[Category: Tempel, W]] | ||
| + | [[Category: Walker, J R]] | ||
| + | [[Category: Gene regulation]] | ||
| + | [[Category: Sgc]] | ||
Revision as of 09:23, 25 December 2019
Crystal Structure of chromodomain of MPP8 in complex with inhibitor UNC3866
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