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6kuy
From Proteopedia
(Difference between revisions)
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<StructureSection load='6kuy' size='340' side='right'caption='[[6kuy]], [[Resolution|resolution]] 3.20Å' scene=''> | <StructureSection load='6kuy' size='340' side='right'caption='[[6kuy]], [[Resolution|resolution]] 3.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6kuy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KUY OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6kuy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KUY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KUY FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=E39:(2~{S})-4-fluoranyl-2-(1~{H}-imidazol-5-yl)-1-propan-2-yl-2,3-dihydroindole'>E39</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E39:(2~{S})-4-fluoranyl-2-(1~{H}-imidazol-5-yl)-1-propan-2-yl-2,3-dihydroindole'>E39</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kuy OCA], [https://pdbe.org/6kuy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kuy RCSB], [https://www.ebi.ac.uk/pdbsum/6kuy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kuy ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ADA2A_HUMAN ADA2A_HUMAN] Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.<ref>PMID:23105096</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Adrenergic receptor 3D structures|Adrenergic receptor 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Qu | + | [[Category: Qu L]] |
| - | [[Category: Wu | + | [[Category: Wu D]] |
| - | [[Category: Zhao | + | [[Category: Zhao SW]] |
| - | [[Category: Zhou | + | [[Category: Zhou QT]] |
| - | + | ||
| - | + | ||
| - | + | ||
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Current revision
Crystal structure of the alpha2A adrenergic receptor in complex with a partial agonist
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Categories: Homo sapiens | Large Structures | Qu L | Wu D | Zhao SW | Zhou QT
