6uwm

From Proteopedia

(Difference between revisions)

Revision as of 09:51, 8 January 2020

Single particle cryo-EM structure of KvAP

Structural highlights

6uwm is a 4 chain structure with sequence from Aerpx. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	APE_0955 (AERPX)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[KVAP_AERPE] Mediates a strong voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Publication Abstract from PubMed

Conductance in voltage-gated ion channels is regulated by membrane voltage through structural domains known as voltage sensors. A single structural class of voltage sensor domain exists, but two different modes of voltage sensor attachment to the pore occur in nature: domain-swapped and non-domain-swapped. Since the more thoroughly studied Kv1-7, Nav and Cav channels have domain-swapped voltage sensors, much less is known about non-domain-swapped voltage-gated ion channels. In this paper, using cryo-EM, we show that KvAP from Aeropyrum pernix has non-domain-swapped voltage sensors as well as other unusual features. The new structure, together with previous functional data, suggests that KvAP and the Shaker channel, to which KvAP is most often compared, probably undergo rather different voltage-dependent conformational changes when they open.

Cryo-EM structure of the KvAP channel reveals a non-domain-swapped voltage sensor topology.,Tao X, MacKinnon R Elife. 2019 Nov 22;8. pii: 52164. doi: 10.7554/eLife.52164. PMID:31755864^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Tao X, MacKinnon R. Cryo-EM structure of the KvAP channel reveals a non-domain-swapped voltage sensor topology. Elife. 2019 Nov 22;8. pii: 52164. doi: 10.7554/eLife.52164. PMID:31755864 doi:http://dx.doi.org/10.7554/eLife.52164

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6uwm"

@@ Line 3: / Line 3: @@
 <StructureSection load='6uwm' size='340' side='right'caption='[[6uwm]], [[Resolution|resolution]] 5.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6uwm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UWM FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6uwm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Aerpx Aerpx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UWM FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uwm OCA], [http://pdbe.org/6uwm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uwm RCSB], [http://www.ebi.ac.uk/pdbsum/6uwm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uwm ProSAT]</span></td></tr>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">APE_0955 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=56636 AERPX])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uwm OCA], [http://pdbe.org/6uwm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uwm RCSB], [http://www.ebi.ac.uk/pdbsum/6uwm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uwm ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 21: / Line 22: @@
 __TOC__
 </StructureSection>
+[[Category: Aerpx]]
 [[Category: Large Structures]]
 [[Category: MacKinnon, R]]

6uwm

From Proteopedia

Revision as of 09:51, 8 January 2020

Single particle cryo-EM structure of KvAP

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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