4rhn
From Proteopedia
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| - | [[Image:4rhn.gif|left|200px]]<br /> | + | [[Image:4rhn.gif|left|200px]]<br /><applet load="4rhn" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="4rhn" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="4rhn, resolution 1.90Å" /> | caption="4rhn, resolution 1.90Å" /> | ||
'''HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (HINT) FROM RABBIT COMPLEXED WITH ADENOSINE'''<br /> | '''HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (HINT) FROM RABBIT COMPLEXED WITH ADENOSINE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 4RHN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus] with RIB as [http://en.wikipedia.org/wiki/ligand ligand]. | + | 4RHN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus] with RIB as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=HIT:The HIS Triad Forms Part Of Alpha Phosphate-Binding Loop ...'>HIT</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=4RHN OCA]. |
==Reference== | ==Reference== | ||
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[[Category: nucleotide-binding protein]] | [[Category: nucleotide-binding protein]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 20:45:25 2007'' |
Revision as of 18:35, 18 December 2007
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HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (HINT) FROM RABBIT COMPLEXED WITH ADENOSINE
Overview
Histidine triad nucleotide-binding protein (HINT), a dimeric purine, nucleotide-binding protein from rabbit heart, is a member of the HIT, (histidine triad) superfamily which includes HINT homologues and FHIT (HIT, protein encoded at the chromosome 3 fragile site) homologues. Crystal, structures of HINT-nucleotide complexes demonstrate that the most, conserved residues in the superfamily mediate nucleotide binding and that, the HIT motif forms part of the phosphate binding loop., Galactose-1-phosphate uridylyltransferase, whose deficiency causes, galactosemia, contains tandem HINT domains with the same fold and mode of, nucleotide binding as HINT despite having no overall sequence similarity., Features of FHIT, a diadenosine polyphosphate hydrolase and candidate, tumour suppressor, are predicted from HINT-nucleotide structures.
About this Structure
4RHN is a Single protein structure of sequence from Oryctolagus cuniculus with RIB as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins., Brenner C, Garrison P, Gilmour J, Peisach D, Ringe D, Petsko GA, Lowenstein JM, Nat Struct Biol. 1997 Mar;4(3):231-8. PMID:9164465
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