Sandbox Reserved 1095
From Proteopedia
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== History == | == History == | ||
| - | Searchers suspected since 70s the existence of diffrents angiotensin receptors. But it was only at the end of 80s that searchers had tools to identify these two distincts transmembrane receptors (AT1R and AT2R)<ref>. Three labs discoveredin the same time these two receptors so they were some confusion about the nomenclature. So In 1991 a group of searchers met to make the nomenclature coherent. Finally, around 2015, researchers the crystal structure of the receptor in complex with its antagonist ZD7155 and with an inverse agonist olmesartan | + | Searchers suspected since 70s the existence of diffrents angiotensin receptors. But it was only at the end of 80s that searchers had tools to identify these two distincts transmembrane receptors (AT1R and AT2R)<ref>. Three labs discoveredin the same time these two receptors so they were some confusion about the nomenclature. So In 1991 a group of searchers met to make the nomenclature coherent. Finally, around 2015, researchers the crystal structure of the receptor in complex with its antagonist ZD7155 and with an inverse agonist olmesartan <ref>. They used x-ray cryogenic-crystallography. They found similar conformation of the receptor when it is link to the antagonist or to the inverse agonist. They also found conserved molecular recognition modes. So to complet the discovery, they realized some experiment with mutants to identify the différents residus which interact with the ligand. |
== Structure/Function relationship == | == Structure/Function relationship == | ||
Revision as of 13:57, 8 December 2019
| This Sandbox is Reserved from 25/11/2019, through 30/9/2020 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1091 through Sandbox Reserved 1115. |
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Crystal Structure of Human Angiotensin Receptor in Complex with Inverse Agonist Olmesartan at 2.8A resolution.
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ . Three labs discoveredin the same time these two receptors so they were some confusion about the nomenclature. So In 1991 a group of searchers met to make the nomenclature coherent. Finally, around 2015, researchers the crystal structure of the receptor in complex with its antagonist ZD7155 and with an inverse agonist olmesartan <ref>. They used x-ray cryogenic-crystallography. They found similar conformation of the receptor when it is link to the antagonist or to the inverse agonist. They also found conserved molecular recognition modes. So to complet the discovery, they realized some experiment with mutants to identify the différents residus which interact with the ligand. == Structure/Function relationship == == Application in the therapeutic field == This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. </li></ol></ref>
