Sandbox Reserved 1095
From Proteopedia
(Difference between revisions)
(Modification of the title, correction of some orthography mistakes in the part "History", adding a sentence in the part "application in the therapeutic field", detail the part structure (draft)) |
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{{Sandbox_ESBS_2019}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | {{Sandbox_ESBS_2019}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
| - | == | + | == Human Angiotensin Receptor == |
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
== Function == | == Function == | ||
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== History == | == History == | ||
| - | Searchers suspected since 70s the existence of | + | Searchers suspected since 70s the existence of different angiotensin receptors. But it was only at the end of 80s that searchers had tools to identify these two distinct trans-membrane receptors (AT1R and AT2R)<ref> </ref>. Three labs discovered in the same time these two receptors so they were some confusion about the nomenclature. So in 1991 a group of searchers met to define a coherent nomenclature. ''Finally, around 2015, researchers the crystal structure of the receptor in complex with its antagonist ZD7155 and with an inverse agonist olmesartan'' <ref> </ref>. They used x-ray cryogenic-crystallography. They found similar conformation of the receptor when it is linked to the antagonist or to the inverse agonist. They also found conserved molecular recognition modes. So to complete the discovery, they realized some experiments with mutants to identify the different residues which interact with the ligand. |
| - | == Structure/Function relationship == | + | == Structure/''Function relationship'' == |
| + | |||
| + | === Primary and secondary structure === | ||
| + | 376 amino acids | ||
== Application in the therapeutic field == | == Application in the therapeutic field == | ||
| + | |||
| + | Since angiotensin receptor is involved in the renin-angiotenisin system, it represents a choice target to cure some diseases like hypertension or heart failure. | ||
| - | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | |||
| + | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
Revision as of 18:33, 7 January 2020
| This Sandbox is Reserved from 25/11/2019, through 30/9/2020 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1091 through Sandbox Reserved 1115. |
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Human Angiotensin Receptor
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References
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
