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Hepatocyte growth factor

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Line 12: Line 12:
{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
-
*HGF N terminal
+
*HGF N terminal 28-126
**[[2hgf]] – hHGF N terminal – human - NMR <br />
**[[2hgf]] – hHGF N terminal – human - NMR <br />
Line 18: Line 18:
**[[3hmr]] – mHGF N terminal – mouse <br />
**[[3hmr]] – mHGF N terminal – mouse <br />
-
*HGF NK1 variant
+
*HGF NK1 variant 28-210
**[[1bht]], [[1nk1]], [[1gp9]], [[2qj2]], [[2qj4]] – hHGF NK1 <br />
**[[1bht]], [[1nk1]], [[1gp9]], [[2qj2]], [[2qj4]] – hHGF NK1 <br />
Line 25: Line 25:
**[[5ct1]], [[5ct2]], [[5ct3]], [[5cs3]], [[5csq]], [[5cp9]] – hHGF NK1 (mutant) + inhibitor<br />
**[[5ct1]], [[5ct2]], [[5ct3]], [[5cs3]], [[5csq]], [[5cp9]] – hHGF NK1 (mutant) + inhibitor<br />
-
*HGF NK2 variant
+
*HGF NK2 variant 28-289
**[[3hn4]] – hHGF NK2 <br />
**[[3hn4]] – hHGF NK2 <br />
Line 31: Line 31:
**[[4iua]] – mHGF NK2 (mutant) <br />
**[[4iua]] – mHGF NK2 (mutant) <br />
-
*HGF α chain (69 kD)
+
* HGF α chain (69 kD) 495-728
-
**[[4o3t]], [[4o3u]] – hHGF α chain (mutant) + HGF receptor Sema and ψ domains + zymogen activator peptide<br />
+
**[[1si5]] – hHGF α chain (mutant) <br />
 +
**[[1shy]] – hHGF α chain (mutant) + HGF receptor Sema and ψ domains<br />
-
*HGF β chain
+
*HGF β chain 25-567
-
**[[1si5]] – hHGF β chain (mutant) <br />
+
**[[4o3t]], [[4o3u]] – hHGF β chain (mutant) + HGF receptor Sema and ψ domains + zymogen activator peptide<br />
-
**[[1shy]] – hHGF β chain (mutant) + HGF receptor Sema and ψ domains<br />
+
*HGF α+β chain
*HGF α+β chain
**[[4k3j]] – hHGF α (mutant) + β + antibody <br />
**[[4k3j]] – hHGF α (mutant) + β + antibody <br />
 +
**[[6lz9]] – hHGF α (mutant) + K4 domain 388-494 + antibody <br />
 +
}}
 +
== References ==
== References ==
<references/>
<references/>
-
}}
+
 
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:44, 17 August 2020

Structure of human HGF β chain (grey) complex with HGF receptor Sema and ψ domains (green) (PDB entry 1shy)

Drag the structure with the mouse to rotate

3D structures of hepatocyte growth factor

Updated on 17-August-2020

References

  1. ↑ Nakamura T. Structure and function of hepatocyte growth factor. Prog Growth Factor Res. 1991;3(1):67-85. PMID:1838014
  2. ↑ Jakubczak JL, LaRochelle WJ, Merlino G. NK1, a natural splice variant of hepatocyte growth factor/scatter factor, is a partial agonist in vivo. Mol Cell Biol. 1998 Mar;18(3):1275-83. PMID:9488442
  3. ↑ Shiota G, Okano J, Kawasaki H, Kawamoto T, Nakamura T. Serum hepatocyte growth factor levels in liver diseases: clinical implications. Hepatology. 1995 Jan;21(1):106-12. PMID:7806142
  4. ↑ Anan F, Masaki T, Yonemochi H, Takahashi N, Nakagawa M, Eshima N, Saikawa T, Yoshimatsu H. Hepatocyte growth factor levels are associated with the results of 123I-metaiodobenzylguanidine myocardial scintigraphy in patients with type 2 diabetes mellitus. Metabolism. 2009 Feb;58(2):167-73. doi: 10.1016/j.metabol.2008.09.009. PMID:19154948 doi:http://dx.doi.org/10.1016/j.metabol.2008.09.009
  5. ↑ Shiota G, Okano J, Kawasaki H, Kawamoto T, Nakamura T. Serum hepatocyte growth factor levels in liver diseases: clinical implications. Hepatology. 1995 Jan;21(1):106-12. PMID:7806142
  6. ↑ Funakoshi H, Nakamura T. Hepatocyte growth factor: from diagnosis to clinical applications. Clin Chim Acta. 2003 Jan;327(1-2):1-23. PMID:12482615

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