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6tmr
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Mokola virus glycoprotein, monomeric post-fusion conformation== | |
| - | + | <StructureSection load='6tmr' size='340' side='right'caption='[[6tmr]], [[Resolution|resolution]] 2.89Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6tmr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TMR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TMR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TB:TERBIUM(III)+ION'>TB</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tmr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tmr OCA], [http://pdbe.org/6tmr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tmr RCSB], [http://www.ebi.ac.uk/pdbsum/6tmr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tmr ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GLYCO_MOKV GLYCO_MOKV]] Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Albertini, A]] | ||
| + | [[Category: Belot, L]] | ||
| + | [[Category: Gaudin, Y]] | ||
| + | [[Category: Legrand, P]] | ||
| + | [[Category: Roche, S]] | ||
| + | [[Category: Class iii fusion protein]] | ||
| + | [[Category: Envelope protein]] | ||
| + | [[Category: Glycoprotein]] | ||
| + | [[Category: Membrane fusion]] | ||
| + | [[Category: Mokola virus]] | ||
| + | [[Category: Receptor binding]] | ||
| + | [[Category: Rhabdovirus]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 06:38, 19 February 2020
Mokola virus glycoprotein, monomeric post-fusion conformation
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