6uvo
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of antibody 3G12 bound to the central conserved domain of RSV G== | |
| - | + | <StructureSection load='6uvo' size='340' side='right'caption='[[6uvo]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6uvo]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UVO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uvo OCA], [http://pdbe.org/6uvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uvo RCSB], [http://www.ebi.ac.uk/pdbsum/6uvo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uvo ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GLYC_HRSVA GLYC_HRSVA]] Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities. Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Castrejon, A M.Nunez]] | ||
| + | [[Category: Dillen, J]] | ||
| + | [[Category: DuBois, R M]] | ||
| + | [[Category: Fedechkin, S O]] | ||
| + | [[Category: George, N L]] | ||
| + | [[Category: Kauvar, L M]] | ||
| + | [[Category: Antibody]] | ||
| + | [[Category: G glycoprotein]] | ||
| + | [[Category: Glycoprotein]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Rsv]] | ||
| + | [[Category: Viral attachment protein]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 08:02, 18 December 2019
Structure of antibody 3G12 bound to the central conserved domain of RSV G
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