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5fi8

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Current revision (06:52, 19 July 2023) (edit) (undo)
 
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<StructureSection load='5fi8' size='340' side='right'caption='[[5fi8]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
<StructureSection load='5fi8' size='340' side='right'caption='[[5fi8]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5fi8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FI8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FI8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5fi8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FI8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FI8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5Y5:2-[1,1-BIS(FLUORANYL)ETHYL]-~{N}-[(2~{S})-7-BROMANYL-1,2,3,4-TETRAHYDRONAPHTHALEN-2-YL]-5-METHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE'>5Y5</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.32&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PFF0160c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5Y5:2-[1,1-BIS(FLUORANYL)ETHYL]-~{N}-[(2~{S})-7-BROMANYL-1,2,3,4-TETRAHYDRONAPHTHALEN-2-YL]-5-METHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE'>5Y5</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fi8 OCA], [https://pdbe.org/5fi8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fi8 RCSB], [https://www.ebi.ac.uk/pdbsum/5fi8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fi8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fi8 OCA], [http://pdbe.org/5fi8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fi8 RCSB], [http://www.ebi.ac.uk/pdbsum/5fi8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fi8 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PYRD_PLAF7 PYRD_PLAF7]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
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[https://www.uniprot.org/uniprot/PYRD_PLAF7 PYRD_PLAF7] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Plaf7]]
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[[Category: Plasmodium falciparum 3D7]]
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[[Category: Deng, X]]
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[[Category: Deng X]]
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[[Category: Kokkonda, S]]
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[[Category: Kokkonda S]]
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[[Category: Phillips, M]]
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[[Category: Phillips M]]
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[[Category: Tomchick, D]]
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[[Category: Tomchick D]]
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[[Category: Alpha/beta barrel]]
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[[Category: Fmn]]
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[[Category: Inhibitor]]
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[[Category: Oxidoreductase / oxidoreductase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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Current revision

Crystal structure of plasmodium falciparum dihydroorotate dehydrogenase bounded with DSM422 (Tetrahydro-2-naphthyl and 2-indanyl triazolopyrimidine)

PDB ID 5fi8

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OCA

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