1a36

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[[Image:1a36.gif|left|200px]]
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==Overview==
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{{ABSTRACT_9488652}}
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The three-dimensional structure of a 70-kilodalton amino terminally truncated form of human topoisomerase I in complex with a 22-base pair duplex oligonucleotide, determined to a resolution of 2.8 angstroms, reveals all of the structural elements of the enzyme that contact DNA. The linker region that connects the central core of the enzyme to the carboxyl-terminal domain assumes a coiled-coil configuration and protrudes away from the remainder of the enzyme. The positively charged DNA-proximal surface of the linker makes only a few contacts with the DNA downstream of the cleavage site. In combination with the crystal structures of the reconstituted human topoisomerase I before and after DNA cleavage, this information suggests which amino acid residues are involved in catalyzing phosphodiester bond breakage and religation. The structures also lead to the proposal that the topoisomerization step occurs by a mechanism termed "controlled rotation."
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==About this Structure==
==About this Structure==
1A36 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1A36 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb73_1.html Topoisomerases]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A36 OCA].
1A36 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1A36 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb73_1.html Topoisomerases]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A36 OCA].
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==Reference==
 
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A model for the mechanism of human topoisomerase I., Stewart L, Redinbo MR, Qiu X, Hol WG, Champoux JJ, Science. 1998 Mar 6;279(5356):1534-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9488652 9488652]
 
[[Category: DNA topoisomerase]]
[[Category: DNA topoisomerase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Dna]]
[[Category: Dna]]
[[Category: Topoisomerase i]]
[[Category: Topoisomerase i]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:44:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:01:59 2008''

Revision as of 14:01, 26 June 2008

Image:1a36.png


PDB ID 1a36

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1a36, resolution 2.80Å ()
Activity: DNA topoisomerase, with EC number 5.99.1.2
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



TOPOISOMERASE I/DNA COMPLEX


Template:ABSTRACT 9488652

About this Structure

1A36 is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1A36 with [Topoisomerases]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:01:59 2008

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