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5vj2

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Current revision (14:10, 13 March 2024) (edit) (undo)
 
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<StructureSection load='5vj2' size='340' side='right'caption='[[5vj2]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
<StructureSection load='5vj2' size='340' side='right'caption='[[5vj2]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5vj2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Respiratory_syncytial_virus_subsp._a Respiratory syncytial virus subsp. a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VJ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VJ2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5vj2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Respiratory_syncytial_virus_type_A Respiratory syncytial virus type A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VJ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VJ2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.22&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1439707 Respiratory syncytial virus subsp. A])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vj2 OCA], [http://pdbe.org/5vj2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vj2 RCSB], [http://www.ebi.ac.uk/pdbsum/5vj2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vj2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vj2 OCA], [https://pdbe.org/5vj2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vj2 RCSB], [https://www.ebi.ac.uk/pdbsum/5vj2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vj2 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/X5FN71_HRSV X5FN71_HRSV]
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Human respiratory syncytial virus (hRSV) is a major cause of morbidity and mortality in the paediatric, elderly and immune-compromised populations1,2. A gap in our understanding of hRSV disease pathology is the interplay between virally encoded immune antagonists and host components that limit hRSV replication. hRSV encodes for non-structural (NS) proteins that are important immune antagonists3-6; however, the role of these proteins in viral pathogenesis is incompletely understood. Here, we report the crystal structure of hRSV NS1 protein, which suggests that NS1 is a structural paralogue of hRSV matrix (M) protein. Comparative analysis of the shared structural fold with M revealed regions unique to NS1. Studies on NS1 wild type or mutant alone or in recombinant RSVs demonstrate that structural regions unique to NS1 contribute to modulation of host responses, including inhibition of type I interferon responses, suppression of dendritic cell maturation and promotion of inflammatory responses. Transcriptional profiles of A549 cells infected with recombinant RSVs show significant differences in multiple host pathways, suggesting that NS1 may have a greater role in regulating host responses than previously appreciated. These results provide a framework to target NS1 for therapeutic development to limit hRSV-associated morbidity and mortality.
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Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses.,Chatterjee S, Luthra P, Esaulova E, Agapov E, Yen BC, Borek DM, Edwards MR, Mittal A, Jordan DS, Ramanan P, Moore ML, Pappu RV, Holtzman MJ, Artyomov MN, Basler CF, Amarasinghe GK, Leung DW Nat Microbiol. 2017 Jun 30;2:17101. doi: 10.1038/nmicrobiol.2017.101. PMID:28665409<ref>PMID:28665409</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5vj2" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Nonstructural protein 3D structures|Nonstructural protein 3D structures]]
*[[Nonstructural protein 3D structures|Nonstructural protein 3D structures]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Respiratory syncytial virus subsp. a]]
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[[Category: Respiratory syncytial virus type A]]
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[[Category: Amarasinghe, G K]]
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[[Category: Amarasinghe GK]]
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[[Category: Borek, D M]]
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[[Category: Borek DM]]
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[[Category: Leung, D W]]
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[[Category: Leung DW]]
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[[Category: Immune modulator]]
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[[Category: Rsv]]
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[[Category: Viral protein]]
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Current revision

Structure of human respiratory syncytial virus non-structural protein 1 (NS1)

PDB ID 5vj2

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