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5vk2

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Current revision (13:50, 4 October 2023) (edit) (undo)
 
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<StructureSection load='5vk2' size='340' side='right'caption='[[5vk2]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='5vk2' size='340' side='right'caption='[[5vk2]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5vk2]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lassj Lassj]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VK2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5vk2]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lassa_virus_Josiah Lassa virus Josiah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VK2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.201&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GPC, GP-C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11622 LASSJ])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vk2 OCA], [http://pdbe.org/5vk2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vk2 RCSB], [http://www.ebi.ac.uk/pdbsum/5vk2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vk2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vk2 OCA], [https://pdbe.org/5vk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vk2 RCSB], [https://www.ebi.ac.uk/pdbsum/5vk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vk2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GLYC_LASSJ GLYC_LASSJ]] Stable signal peptide (SSP) is cleaved but is apparently retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational cleavage of GP1 and GP2, glycoprotein transport to the cell plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion. The GP complex interacts with host glycosylated LAMP1 to mediate efficient infection.<ref>PMID:24970085</ref> Glycoprotein G1 mediates virus attachment to host receptor alpha-dystroglycan DAG1. This attachment induces virion internalization predominantly through clathrin- and caveolin-independent endocytosis. Glycoprotein G2 is a class I viral fusion protein, that directs fusion of viral and host endosomal membranes, leading to delivery of the nucleocapsid into the cytoplasm. Membrane fusion is mediated by irreversable conformational changes induced upon acidification in the endosome (By similarity).
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[https://www.uniprot.org/uniprot/GLYC_LASSJ GLYC_LASSJ] Stable signal peptide (SSP) is cleaved but is apparently retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational cleavage of GP1 and GP2, glycoprotein transport to the cell plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion. The GP complex interacts with host glycosylated LAMP1 to mediate efficient infection.<ref>PMID:24970085</ref> Glycoprotein G1 mediates virus attachment to host receptor alpha-dystroglycan DAG1. This attachment induces virion internalization predominantly through clathrin- and caveolin-independent endocytosis. Glycoprotein G2 is a class I viral fusion protein, that directs fusion of viral and host endosomal membranes, leading to delivery of the nucleocapsid into the cytoplasm. Membrane fusion is mediated by irreversable conformational changes induced upon acidification in the endosome (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lassj]]
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[[Category: Lassa virus Josiah]]
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[[Category: Branco, L M]]
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[[Category: Branco LM]]
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[[Category: Chandra, K]]
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[[Category: Chandra K]]
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[[Category: Garry, R F]]
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[[Category: Garry RF]]
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[[Category: Hastie, K M]]
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[[Category: Hastie KM]]
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[[Category: Kleinfelter, L M]]
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[[Category: Kleinfelter LM]]
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[[Category: Robinson, J E]]
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[[Category: Robinson JE]]
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[[Category: Rowland, M L]]
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[[Category: Rowland ML]]
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[[Category: Rowland, M M]]
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[[Category: Rowland MM]]
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[[Category: Saphire, E O]]
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[[Category: Saphire EO]]
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[[Category: Zandonatti, M A]]
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[[Category: Zandonatti MA]]
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[[Category: Antibody]]
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[[Category: Arenavirus]]
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[[Category: Glycoprotein]]
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[[Category: Lassa]]
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[[Category: Viral protein-immune system complex]]
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Current revision

Structural basis for antibody-mediated neutralization of Lassa virus

PDB ID 5vk2

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OCA

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