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5vpe

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Current revision (13:54, 4 October 2023) (edit) (undo)
 
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<StructureSection load='5vpe' size='340' side='right'caption='[[5vpe]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
<StructureSection load='5vpe' size='340' side='right'caption='[[5vpe]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5vpe]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VPE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VPE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5vpe]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VPE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VPE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.053&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vpa|5vpa]], [[5vpb|5vpb]], [[5vpc|5vpc]], [[5vpd|5vpd]], [[5vpf|5vpf]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FOSB, G0S3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), JUND ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vpe OCA], [https://pdbe.org/5vpe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vpe RCSB], [https://www.ebi.ac.uk/pdbsum/5vpe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vpe ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vpe OCA], [http://pdbe.org/5vpe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vpe RCSB], [http://www.ebi.ac.uk/pdbsum/5vpe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vpe ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FOSB_HUMAN FOSB_HUMAN]] FosB interacts with Jun proteins enhancing their DNA binding activity. [[http://www.uniprot.org/uniprot/JUND_HUMAN JUND_HUMAN]] Transcription factor binding AP-1 sites.<ref>PMID:9989505</ref>
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[https://www.uniprot.org/uniprot/FOSB_HUMAN FOSB_HUMAN] FosB interacts with Jun proteins enhancing their DNA binding activity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Machius, M]]
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[[Category: Machius M]]
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[[Category: Rudenko, G]]
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[[Category: Rudenko G]]
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[[Category: Yin, Z]]
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[[Category: Yin Z]]
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[[Category: Activator protein-1]]
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[[Category: Basic leucine zipper]]
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[[Category: Bzip]]
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[[Category: Coiled-coil]]
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[[Category: Dna-binding protein]]
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[[Category: Fo]]
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[[Category: Jun]]
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[[Category: Redox switch]]
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[[Category: Transcription factor]]
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[[Category: Transcription-dna complex]]
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Current revision

Transcription factor FosB/JunD bZIP domain in complex with cognate DNA, type-I crystal

PDB ID 5vpe

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