6neh

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Current revision (14:47, 13 March 2024) (edit) (undo)
 
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<StructureSection load='6neh' size='340' side='right'caption='[[6neh]], [[Resolution|resolution]] 1.52&Aring;' scene=''>
<StructureSection load='6neh' size='340' side='right'caption='[[6neh]], [[Resolution|resolution]] 1.52&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6neh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NEH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NEH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6neh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thalictrum_flavum_subsp._glaucum Thalictrum flavum subsp. glaucum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NEH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NEH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SLX:(13AS)-3,10-DIMETHOXY-5,8,13,13A-TETRAHYDRO-6H-ISOQUINO[3,2-A]ISOQUINOLINE-2,9-DIOL'>SLX</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.52&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(S)-scoulerine_9-O-methyltransferase (S)-scoulerine 9-O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.117 2.1.1.117] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SLX:(13AS)-3,10-DIMETHOXY-5,8,13,13A-TETRAHYDRO-6H-ISOQUINO[3,2-A]ISOQUINOLINE-2,9-DIOL'>SLX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6neh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6neh OCA], [http://pdbe.org/6neh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6neh RCSB], [http://www.ebi.ac.uk/pdbsum/6neh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6neh ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6neh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6neh OCA], [https://pdbe.org/6neh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6neh RCSB], [https://www.ebi.ac.uk/pdbsum/6neh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6neh ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q5C9L2_THLFG Q5C9L2_THLFG]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Payne, J T]]
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[[Category: Thalictrum flavum subsp. glaucum]]
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[[Category: Smolke, C D]]
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[[Category: Payne JT]]
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[[Category: Valentic, T R]]
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[[Category: Smolke CD]]
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[[Category: Benzylisoquinoline alkaloid]]
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[[Category: Valentic TR]]
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[[Category: Biosynthetic protein]]
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[[Category: Methyltransferase]]
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[[Category: Plant natural product]]
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[[Category: Scoulerine]]
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Current revision

N191D, F205S mutant of scoulerine 9-O-methyltransferase from Thalictrum flavum complexed with (13aS)-3,10-dimethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline-2,9-diol and S-ADENOSYL-L-HOMOCYSTEINE

PDB ID 6neh

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