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1a4j

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[[Image:1a4j.gif|left|200px]]
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{{Seed}}
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[[Image:1a4j.png|left|200px]]
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{{STRUCTURE_1a4j| PDB=1a4j | SCENE= }}
{{STRUCTURE_1a4j| PDB=1a4j | SCENE= }}
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'''DIELS ALDER CATALYTIC ANTIBODY GERMLINE PRECURSOR'''
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===DIELS ALDER CATALYTIC ANTIBODY GERMLINE PRECURSOR===
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==Overview==
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The three-dimensional structure of an antibody (39-A11) that catalyzes a Diels-Alder reaction has been determined. The structure suggests that the antibody catalyzes this pericyclic reaction through a combination of packing and hydrogen-bonding interactions that control the relative geometries of the bound substrates and electronic distribution in the dienophile. A single somatic mutation, serine-91 of the light chain to valine, is largely responsible for the increase in affinity and catalytic activity of the affinity-matured antibody. Structural and functional studies of the germ-line precursor suggest that 39-A11 and related antibodies derive from a family of germ-line genes that have been selected throughout evolution for the ability of the encoded proteins to form a polyspecific combining site. Germ line-encoded antibodies of this type, which can rapidly evolve into high-affinity receptors for a broad range of structures, may help to expand the binding potential associated with the structural diversity of the primary antibody repertoire.
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The line below this paragraph, {{ABSTRACT_PUBMED_9506942}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9506942 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9506942}}
==About this Structure==
==About this Structure==
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[[Category: Germline]]
[[Category: Germline]]
[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:48:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:06:25 2008''

Revision as of 13:06, 30 June 2008

Image:1a4j.png

Template:STRUCTURE 1a4j

DIELS ALDER CATALYTIC ANTIBODY GERMLINE PRECURSOR

Template:ABSTRACT PUBMED 9506942

About this Structure

1A4J is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Immunological origins of binding and catalysis in a Diels-Alderase antibody., Romesberg FE, Spiller B, Schultz PG, Stevens RC, Science. 1998 Mar 20;279(5358):1929-33. PMID:9506942

Page seeded by OCA on Mon Jun 30 16:06:25 2008

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