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4kqz

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<StructureSection load='4kqz' size='340' side='right'caption='[[4kqz]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
<StructureSection load='4kqz' size='340' side='right'caption='[[4kqz]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4kqz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_betacoronavirus_2c_emc/2012 Human betacoronavirus 2c emc/2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KQZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4kqz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_betacoronavirus_2c_EMC/2012 Human betacoronavirus 2c EMC/2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KQZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kr0|4kr0]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kqz OCA], [https://pdbe.org/4kqz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kqz RCSB], [https://www.ebi.ac.uk/pdbsum/4kqz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kqz ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">S, spike ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1235996 Human betacoronavirus 2c EMC/2012])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kqz OCA], [http://pdbe.org/4kqz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kqz RCSB], [http://www.ebi.ac.uk/pdbsum/4kqz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kqz ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/K0BRG7_MERS K0BRG7_MERS] Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.[HAMAP-Rule:MF_04099] Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099] Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4kqz" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4kqz" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Sandbox 3001|Sandbox 3001]]
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*[[Spike protein|Spike protein]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human betacoronavirus 2c emc/2012]]
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[[Category: Human betacoronavirus 2c EMC/2012]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bao, J]]
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[[Category: Bao J]]
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[[Category: Gao, F]]
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[[Category: Gao F]]
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[[Category: Gao, G F]]
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[[Category: Gao GF]]
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[[Category: Hu, Y]]
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[[Category: Hu Y]]
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[[Category: Li, Y]]
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[[Category: Li Y]]
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[[Category: Lu, G]]
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[[Category: Lu G]]
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[[Category: Qi, J]]
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[[Category: Qi J]]
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[[Category: Shi, Y]]
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[[Category: Shi Y]]
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[[Category: Wang, Q]]
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[[Category: Wang Q]]
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[[Category: Yan, J]]
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[[Category: Yan J]]
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[[Category: Yuan, Y]]
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[[Category: Yuan Y]]
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[[Category: Zhang, B]]
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[[Category: Zhang B]]
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[[Category: Zhang, W]]
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[[Category: Zhang W]]
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[[Category: Zhang, Y]]
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[[Category: Zhang Y]]
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[[Category: Cd26]]
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[[Category: Core subdomain]]
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[[Category: Receptor binding]]
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[[Category: Strand-dominated receptor binding motif]]
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[[Category: Viral protein]]
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[[Category: Viral surface]]
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Revision as of 09:08, 7 December 2022

structure of the receptor binding domain (RBD) of MERS-CoV spike

PDB ID 4kqz

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OCA

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