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1a4o

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[[Image:1a4o.gif|left|200px]]
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{{Seed}}
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[[Image:1a4o.png|left|200px]]
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{{STRUCTURE_1a4o| PDB=1a4o | SCENE= }}
{{STRUCTURE_1a4o| PDB=1a4o | SCENE= }}
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'''14-3-3 PROTEIN ZETA ISOFORM'''
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===14-3-3 PROTEIN ZETA ISOFORM===
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==Overview==
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The 14-3-3 family of proteins have recently been identified as regulatory elements in intracellular signalling pathways: 14-3-3 proteins bind to oncogene and proto-oncogene products, including c-Raf-1 (refs 2-5), c-Bcr (ref. 6) and polyomavirus middle-T antigen; overexpression of 14-3-3 activates Raf kinase in yeast and induces meiotic maturation in Xenopus oocytes. Here we report the crystal structure of the major isoform of mammalian 14-3-3 proteins at 2.9 A resolution. Each subunit of the dimeric protein consists of a bundle of nine antiparallel helices that form a palisade around an amphipathic groove. The groove is large enough to accommodate a tenth helix, and we propose that binding to an amphipathic helix represents a general mechanism for the interaction of 14-3-3 with diverse cellular proteins. The residues in the dimer interface and the putative ligand-binding surface are invariant among vertebrates, yeast and plants, suggesting a conservation of structure and function throughout the 14-3-3 family.
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The line below this paragraph, {{ABSTRACT_PUBMED_7603574}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7603574 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7603574}}
==About this Structure==
==About this Structure==
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[[Category: Petosa, C.]]
[[Category: Petosa, C.]]
[[Category: Signal transduction]]
[[Category: Signal transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:48:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:07:05 2008''

Revision as of 13:07, 30 June 2008

Image:1a4o.png

Template:STRUCTURE 1a4o

14-3-3 PROTEIN ZETA ISOFORM

Template:ABSTRACT PUBMED 7603574

About this Structure

1A4O is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the zeta isoform of the 14-3-3 protein., Liu D, Bienkowska J, Petosa C, Collier RJ, Fu H, Liddington R, Nature. 1995 Jul 13;376(6536):191-4. PMID:7603574

Page seeded by OCA on Mon Jun 30 16:07:05 2008

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