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1a58

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[[Image:1a58.gif|left|200px]]
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[[Image:1a58.png|left|200px]]
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{{STRUCTURE_1a58| PDB=1a58 | SCENE= }}
{{STRUCTURE_1a58| PDB=1a58 | SCENE= }}
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'''CYCLOPHILIN FROM BRUGIA MALAYI'''
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===CYCLOPHILIN FROM BRUGIA MALAYI===
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==Overview==
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A structure of residues 1-177 of the cyclophilin domain of a large divergent cyclophilin from the filarial nematode parasite Brugia malayi has been crystallised and solved in two different crystal forms. The active site has a similar structure to that of human cyclophilin A. Two of the 13 residues important in forming the human cyclophilin A/cyclosporin A complex are altered in the B. malayi cyclophilin and explain the relatively poor inhibition of peptidyl prolyl isomerase activity by cyclosporin A.
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(as it appears on PubMed at http://www.pubmed.gov), where 9559680 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9559680}}
==About this Structure==
==About this Structure==
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[[Category: Isomerase]]
[[Category: Isomerase]]
[[Category: Ppiase]]
[[Category: Ppiase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:49:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:09:39 2008''

Revision as of 13:09, 30 June 2008

Image:1a58.png

Template:STRUCTURE 1a58

CYCLOPHILIN FROM BRUGIA MALAYI

Template:ABSTRACT PUBMED 9559680

About this Structure

1A58 is a Single protein structure of sequence from Brugia malayi. Full crystallographic information is available from OCA.

Reference

The X-ray structure of a divergent cyclophilin from the nematode parasite Brugia malayi., Taylor P, Page AP, Kontopidis G, Husi H, Walkinshaw MD, FEBS Lett. 1998 Mar 27;425(2):361-6. PMID:9559680

Page seeded by OCA on Mon Jun 30 16:09:39 2008

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