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2utg

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STRUCTURE AND REFINEMENT OF THE OXIDIZED P21 FORM OF UTEROGLOBIN AT 1.64 ANGSTROMS RESOLUTION

Structural highlights

2utg is a 2 chain structure with sequence from European rabbit. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[UTER_RABIT] Uteroglobin binds progesterone specifically and with high affinity. It may regulate progesterone concentrations reaching the blastocyst. It is also a potent inhibitor of phospholipase A2.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

One of the monoclinic P21 forms of uteroglobin, a progesterone-binding protein secreted by the rabbit uterus, was crystallized and subjected to X-ray diffraction analysis at 1.64 A resolution. The analysis was refined to an R factor of 0.19 and the 1096 non-hydrogen atomic positions are known to an accuracy of about 0.18 A. The average isotropic temperature factor B was 10.4 A2. Uteroglobin is a dimer of two independent polypeptide chains of 70 residues linked by two disulfide bridges and related by a pseudo binary axis. Each monomer is folded into four alpha-helices. An oblong hydrophobic pocket is observed inside the dimer, and the possibility that it represents a progesterone-binding site is discussed. The present model includes 165 possible sites for water molecules, of which six are located in the hydrophobic pocket. Polar groups are involved in hydrogen bonding (intramolecular, intermolecular or with water molecules).

Structure and refinement of the oxidized P21 form of uteroglobin at 1.64 A resolution.,Bally R, Delettre J J Mol Biol. 1989 Mar 5;206(1):153-70. PMID:2704039^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Bally R, Delettre J. Structure and refinement of the oxidized P21 form of uteroglobin at 1.64 A resolution. J Mol Biol. 1989 Mar 5;206(1):153-70. PMID:2704039

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2utg"

Categories: European rabbit | Large Structures | Bally, R | Delettre, J | Steroid binding

@@ Line 3: / Line 3: @@
 <StructureSection load='2utg' size='340' side='right'caption='[[2utg]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2utg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UTG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UTG FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2utg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UTG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UTG FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2utg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2utg OCA], [http://pdbe.org/2utg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2utg RCSB], [http://www.ebi.ac.uk/pdbsum/2utg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2utg ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2utg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2utg OCA], [https://pdbe.org/2utg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2utg RCSB], [https://www.ebi.ac.uk/pdbsum/2utg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2utg ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/UTER_RABIT UTER_RABIT]] Uteroglobin binds progesterone specifically and with high affinity. It may regulate progesterone concentrations reaching the blastocyst. It is also a potent inhibitor of phospholipase A2.
+[[https://www.uniprot.org/uniprot/UTER_RABIT UTER_RABIT]] Uteroglobin binds progesterone specifically and with high affinity. It may regulate progesterone concentrations reaching the blastocyst. It is also a potent inhibitor of phospholipase A2.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]

2utg

From Proteopedia

Current revision

STRUCTURE AND REFINEMENT OF THE OXIDIZED P21 FORM OF UTEROGLOBIN AT 1.64 ANGSTROMS RESOLUTION

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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