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4eno

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Current revision (07:19, 28 September 2022) (edit) (undo)
 
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<StructureSection load='4eno' size='340' side='right'caption='[[4eno]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='4eno' size='340' side='right'caption='[[4eno]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4eno]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ENO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ENO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4eno]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ENO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ENO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NME1, NDPKA, NM23 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eno FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eno OCA], [https://pdbe.org/4eno PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eno RCSB], [https://www.ebi.ac.uk/pdbsum/4eno PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eno ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside-diphosphate_kinase Nucleoside-diphosphate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.6 2.7.4.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eno FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eno OCA], [http://pdbe.org/4eno PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4eno RCSB], [http://www.ebi.ac.uk/pdbsum/4eno PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4eno ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NDKA_HUMAN NDKA_HUMAN]] Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination.<ref>PMID:2056128</ref> <ref>PMID:8810265</ref> <ref>PMID:12628186</ref>
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[[https://www.uniprot.org/uniprot/NDKA_HUMAN NDKA_HUMAN]] Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination.<ref>PMID:2056128</ref> <ref>PMID:8810265</ref> <ref>PMID:12628186</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Nucleoside-diphosphate kinase]]
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[[Category: Kim M-S]]
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[[Category: Kim, M S]]
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[[Category: Shin D-H]]
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[[Category: Shin, D H]]
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[[Category: Beta protein]]
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[[Category: Ferredoxin-like/alpha]]
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[[Category: Nucleoside diphosphate kinase]]
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[[Category: Transferase]]
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Current revision

Crystal structure of oxidized human nm23-H1

PDB ID 4eno

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