1a6p

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[[Image:1a6p.gif|left|200px]]
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{{Seed}}
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[[Image:1a6p.png|left|200px]]
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{{STRUCTURE_1a6p| PDB=1a6p | SCENE= }}
{{STRUCTURE_1a6p| PDB=1a6p | SCENE= }}
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'''ENGINEERING OF A MISFOLDED FORM OF CD2'''
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===ENGINEERING OF A MISFOLDED FORM OF CD2===
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==Overview==
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The amino-terminal domain of CD2 has the remarkable ability to fold in two ways: either as a monomer or as an intertwined, metastable dimer. Here we show that it is possible to differentially stabilize either fold by engineering the CD2 sequence, mimicking random mutagenesis events that could occur during molecular evolution. Crystal structures of a hinge-deletion mutant, which is stable as an intertwined dimer, reveal domain rotations that enable the protein to further assemble to a tetramer. These results demonstrate that a variety of folds can be adopted by a single polypeptide sequence, and provide guidance for the design of proteins capable of further assembly.
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The line below this paragraph, {{ABSTRACT_PUBMED_9731771}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9731771 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9731771}}
==About this Structure==
==About this Structure==
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[[Category: Oligomer evolution]]
[[Category: Oligomer evolution]]
[[Category: T lymphocyte adhesion glycoprotein]]
[[Category: T lymphocyte adhesion glycoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:53:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:15:27 2008''

Revision as of 13:15, 30 June 2008

Image:1a6p.png

Template:STRUCTURE 1a6p

ENGINEERING OF A MISFOLDED FORM OF CD2

Template:ABSTRACT PUBMED 9731771

About this Structure

1A6P is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Engineering an intertwined form of CD2 for stability and assembly., Murray AJ, Head JG, Barker JJ, Brady RL, Nat Struct Biol. 1998 Sep;5(9):778-82. PMID:9731771

Page seeded by OCA on Mon Jun 30 16:15:27 2008

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