5jyq

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Current revision (19:15, 20 September 2023) (edit) (undo)
 
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<StructureSection load='5jyq' size='340' side='right'caption='[[5jyq]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='5jyq' size='340' side='right'caption='[[5jyq]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5jyq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JYQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5jyq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_geographus Conus geographus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JYQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CGU:GAMMA-CARBOXY-GLUTAMIC+ACID'>CGU</scene>, <scene name='pdbligand=CY3:2-AMINO-3-MERCAPTO-PROPIONAMIDE'>CY3</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CGU:GAMMA-CARBOXY-GLUTAMIC+ACID'>CGU</scene>, <scene name='pdbligand=CY3:2-AMINO-3-MERCAPTO-PROPIONAMIDE'>CY3</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyq OCA], [http://pdbe.org/5jyq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jyq RCSB], [http://www.ebi.ac.uk/pdbsum/5jyq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyq ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyq OCA], [https://pdbe.org/5jyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jyq RCSB], [https://www.ebi.ac.uk/pdbsum/5jyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyq ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/INS1A_CONGE INS1A_CONGE] This venom insulin, from a fish-hunting cone snail, facilitates prey capture by rapidly inducing hypoglycemic shock (PubMed:25605914, PubMed:27617429). It is one of the smallest known insulin found in nature and lacks the C-terminal segment of the B chain that, in human insulin, mediates engagement of the insulin receptor (INSR) and assembly of the hormone's hexameric storage form (PubMed:27617429). Despite lacking this segment, it both binds and activates human insulin receptor (long isoform (HIR-B)) with a high potency (EC(50)=16.28 nM) (PubMed:30747102, PubMed:27617429). In vivo, intraperitoneal injection of this peptide into zebrafish lowers blood glucose with the same potency than human insulin (PubMed:25605914, PubMed:30747102). In addition, when applied to water, this peptide reduces overall locomotor activity of zebrafish larvae, observed as a significant decrease in the percentage of time spent swimming and movement frequency (PubMed:25605914). When tested on a mouse model of diabetes, this insulin also lowers blood glucose with a 10-fold lower potency than human insulin (PubMed:30747102).<ref>PMID:25605914</ref> <ref>PMID:27617429</ref> <ref>PMID:30747102</ref>
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Conus geographus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lawrence, M C]]
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[[Category: Lawrence MC]]
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[[Category: Menting, J]]
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[[Category: Menting J]]
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[[Category: Norton, R S]]
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[[Category: Norton RS]]
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[[Category: Safavi-Hemami, H]]
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[[Category: Safavi-Hemami H]]
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[[Category: Hormone]]
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[[Category: Venom insulin]]
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Current revision

Structure of Conus Geographus insulin G1

PDB ID 5jyq

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