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6ndl

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Current revision (06:51, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6ndl' size='340' side='right'caption='[[6ndl]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='6ndl' size='340' side='right'caption='[[6ndl]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ndl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/9stap 9stap]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NDL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ndl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NDL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NDL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BQX:1-[4-(6-aminopurin-9-yl)butylsulfamoyl]-3-[4-[(4~{S})-2-oxidanylidene-1,3,3~{a},4,6,6~{a}-hexahydrothieno[3,4-d]imidazol-4-yl]butyl]urea'>BQX</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Biotin--[acetyl-CoA-carboxylase]_ligase Biotin--[acetyl-CoA-carboxylase] ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.15 6.3.4.15] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BQX:1-[4-(6-aminopurin-9-yl)butylsulfamoyl]-3-[4-[(4~{S})-2-oxidanylidene-1,3,3~{a},4,6,6~{a}-hexahydrothieno[3,4-d]imidazol-4-yl]butyl]urea'>BQX</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ndl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ndl OCA], [http://pdbe.org/6ndl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ndl RCSB], [http://www.ebi.ac.uk/pdbsum/6ndl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ndl ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ndl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ndl OCA], [https://pdbe.org/6ndl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ndl RCSB], [https://www.ebi.ac.uk/pdbsum/6ndl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ndl ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q2G258_STAA8 Q2G258_STAA8] Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.[HAMAP-Rule:MF_00978]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6ndl" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6ndl" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Biotin Protein Ligase 3D structures|Biotin Protein Ligase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bruning, J B]]
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[[Category: Staphylococcus aureus]]
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[[Category: Lee, K]]
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[[Category: Bruning JB]]
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[[Category: Marshall, A C]]
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[[Category: Lee K]]
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[[Category: Polyak, S W]]
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[[Category: Marshall AC]]
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[[Category: Amino sulfonylurea]]
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[[Category: Polyak SW]]
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[[Category: Antibiotic]]
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[[Category: Bpl inhibitor]]
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[[Category: Ligase]]
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[[Category: Ligase-ligase inhibitor complex]]
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[[Category: Sulfonamide analogue]]
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Current revision

Crystal structure of Staphylococcus aureus biotin protein ligase in complex with a sulfonamide inhibitor

PDB ID 6ndl

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