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6o6w

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Solution structure of human myeloid-derived growth factor

Structural highlights

6o6w is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MYDGF_HUMAN Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).[UniProtKB:Q9CPT4]^[1]

Publication Abstract from PubMed

Human myeloid-derived growth factor (hMYDGF) is a 142-residue protein with a C-terminal endoplasmic reticulum (ER) retention sequence (ERS). Extracellular MYDGF mediates cardiac repair in mice after anoxic injury. Although homologs of hMYDGF are found in eukaryotes as distant as protozoans, its structure and function are unknown. Here we present the NMR solution structure of hMYDGF, which consists of a short alpha-helix and ten beta-strands distributed in three beta-sheets. Conserved residues map to the unstructured ERS, loops on the face opposite the ERS, and the surface of a cavity underneath the conserved loops. The only protein or portion of a protein known to have a similar fold is the base domain of VNN1. We suggest, in analogy to the tethering of the VNN1 nitrilase domain to the plasma membrane via its base domain, that MYDGF complexed to the KDEL receptor binds cargo via its conserved residues for transport to the ER.

Solution structure of human myeloid-derived growth factor suggests a conserved function in the endoplasmic reticulum.,Bortnov V, Tonelli M, Lee W, Lin Z, Annis DS, Demerdash ON, Bateman A, Mitchell JC, Ge Y, Markley JL, Mosher DF Nat Commun. 2019 Dec 9;10(1):5612. doi: 10.1038/s41467-019-13577-5. PMID:31819058^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Korf-Klingebiel M, Reboll MR, Klede S, Brod T, Pich A, Polten F, Napp LC, Bauersachs J, Ganser A, Brinkmann E, Reimann I, Kempf T, Niessen HW, Mizrahi J, Schonfeld HJ, Iglesias A, Bobadilla M, Wang Y, Wollert KC. Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction. Nat Med. 2015 Feb;21(2):140-9. doi: 10.1038/nm.3778. Epub 2015 Jan 12. PMID:25581518 doi:http://dx.doi.org/10.1038/nm.3778
↑ Bortnov V, Tonelli M, Lee W, Lin Z, Annis DS, Demerdash ON, Bateman A, Mitchell JC, Ge Y, Markley JL, Mosher DF. Solution structure of human myeloid-derived growth factor suggests a conserved function in the endoplasmic reticulum. Nat Commun. 2019 Dec 9;10(1):5612. doi: 10.1038/s41467-019-13577-5. PMID:31819058 doi:http://dx.doi.org/10.1038/s41467-019-13577-5

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6o6w"

@@ Line 1: / Line 1: @@
 ==Solution structure of human myeloid-derived growth factor==
-<StructureSection load='6o6w' size='340' side='right'caption='[[6o6w]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='6o6w' size='340' side='right'caption='[[6o6w]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6o6w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O6W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O6W FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6o6w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O6W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O6W FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MYDGF, C19orf10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o6w OCA], [https://pdbe.org/6o6w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o6w RCSB], [https://www.ebi.ac.uk/pdbsum/6o6w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o6w ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o6w OCA], [http://pdbe.org/6o6w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o6w RCSB], [http://www.ebi.ac.uk/pdbsum/6o6w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o6w ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/MYDGF_HUMAN MYDGF_HUMAN]] Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).[UniProtKB:Q9CPT4]<ref>PMID:25581518</ref>
+[https://www.uniprot.org/uniprot/MYDGF_HUMAN MYDGF_HUMAN] Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).[UniProtKB:Q9CPT4]<ref>PMID:25581518</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 22: / Line 21: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Bortnov, V]]
+[[Category: Bortnov V]]
-[[Category: Lee, W]]
+[[Category: Lee W]]
-[[Category: Markley, J L]]
+[[Category: Markley JL]]
-[[Category: Mosher, D F]]
+[[Category: Mosher DF]]
-[[Category: Tonelli, M]]
+[[Category: Tonelli M]]
-[[Category: Endoplasmic reticulum]]
-[[Category: Unknown function]]
-[[Category: Upf0556]]

6o6w

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Current revision

Solution structure of human myeloid-derived growth factor

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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