This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1a76

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1a76.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1a76.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1a76| PDB=1a76 | SCENE= }}
{{STRUCTURE_1a76| PDB=1a76 | SCENE= }}
-
'''FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII'''
+
===FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII===
-
==Overview==
+
<!--
-
Flap endonuclease-1 (FEN-1), a structure specific nuclease, is an essential enzyme for eukaryotic DNA replication and repair. The crystal structure of FEN-1 from Methanococcus jannaschii, determined at 2.0 A resolution, reveals an active site with two metal ions residing on top of a deep cleft where several conserved acidic residues are clustered. Near the active site, a long flexible loop comprised of many basic and aromatic residues forms a hole large enough to accommodate the DNA substrate. Deletion mutations in this loop significantly decreased the nuclease activity and specificity of FEN-1, suggesting that the loop is critical for recognition and cleavage of the junction between single and double-stranded regions of flap DNA.
+
The line below this paragraph, {{ABSTRACT_PUBMED_9699635}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 9699635 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_9699635}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Rad27]]
[[Category: Rad27]]
[[Category: Rth]]
[[Category: Rth]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:55:02 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:17:24 2008''

Revision as of 13:17, 30 June 2008

Image:1a76.png

Template:STRUCTURE 1a76

FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII

Template:ABSTRACT PUBMED 9699635

About this Structure

1A76 is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

Reference

The crystal structure of flap endonuclease-1 from Methanococcus jannaschii., Hwang KY, Baek K, Kim HY, Cho Y, Nat Struct Biol. 1998 Aug;5(8):707-13. PMID:9699635

Page seeded by OCA on Mon Jun 30 16:17:24 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1a76"
Personal tools