1a77

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{{STRUCTURE_1a77| PDB=1a77 | SCENE= }}
{{STRUCTURE_1a77| PDB=1a77 | SCENE= }}
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'''FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII'''
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===FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII===
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==Overview==
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Flap endonuclease-1 (FEN-1), a structure specific nuclease, is an essential enzyme for eukaryotic DNA replication and repair. The crystal structure of FEN-1 from Methanococcus jannaschii, determined at 2.0 A resolution, reveals an active site with two metal ions residing on top of a deep cleft where several conserved acidic residues are clustered. Near the active site, a long flexible loop comprised of many basic and aromatic residues forms a hole large enough to accommodate the DNA substrate. Deletion mutations in this loop significantly decreased the nuclease activity and specificity of FEN-1, suggesting that the loop is critical for recognition and cleavage of the junction between single and double-stranded regions of flap DNA.
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(as it appears on PubMed at http://www.pubmed.gov), where 9699635 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9699635}}
==About this Structure==
==About this Structure==
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Revision as of 13:17, 30 June 2008

Image:1a77.png

Template:STRUCTURE 1a77

FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII

Template:ABSTRACT PUBMED 9699635

About this Structure

1A77 is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

Reference

The crystal structure of flap endonuclease-1 from Methanococcus jannaschii., Hwang KY, Baek K, Kim HY, Cho Y, Nat Struct Biol. 1998 Aug;5(8):707-13. PMID:9699635

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