2yl2
From Proteopedia
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<StructureSection load='2yl2' size='340' side='right'caption='[[2yl2]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='2yl2' size='340' side='right'caption='[[2yl2]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2yl2]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2yl2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YL2 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yl2 OCA], [https://pdbe.org/2yl2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yl2 RCSB], [https://www.ebi.ac.uk/pdbsum/2yl2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yl2 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN]] Defects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:[https://omim.org/entry/613933 613933]]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.<ref>PMID:6114432</ref> |
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN]] Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.<ref>PMID:20952656</ref> |
==See Also== | ==See Also== | ||
Revision as of 15:06, 17 November 2021
Crystal structure of human acetyl-CoA carboxylase 1, biotin carboxylase (BC) domain
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Categories: Human | Large Structures | Arrowsmith, C H | Beltrami, A | Bountra, C | Delft, F von | Edwards, A M | Froese, D S | Krojer, T | Krysztofinska, E | Muniz, J R.C | Oppermann, U | Vollmar, M | Weigelt, J | Yue, W W | Ligase
