1a7h

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[[Image:1a7h.gif|left|200px]]
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{{Seed}}
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[[Image:1a7h.png|left|200px]]
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{{STRUCTURE_1a7h| PDB=1a7h | SCENE= }}
{{STRUCTURE_1a7h| PDB=1a7h | SCENE= }}
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'''GAMMA S CRYSTALLIN C-TERMINAL DOMAIN'''
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===GAMMA S CRYSTALLIN C-TERMINAL DOMAIN===
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==Overview==
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The 2-domain gammaS-crystallin, a highly conserved early evolutionary off-shoot of the gamma-crystallin family, is located in the water-rich region of eye lenses. The expressed C-terminal domain, gammaS-C, has been crystallized and the 2.56 A X-ray structure determined. There are two domains in the asymmetric unit which pair about a distorted twofold axis. One of the domains has an altered conformation in a highly conserved region of the protein, the tyrosine corner. The distorted gammaS-C dimer of domains is compared with the highly symmetrical, equivalent recombinant dimer of C-terminal domains from gammaB-crystallin. Sequence changes close to the interface, that distinguish gammaS from the other gamma-crystallins, are examined in order to evaluate their role in symmetrical domain pairing.
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The line below this paragraph, {{ABSTRACT_PUBMED_9681865}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9681865 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9681865}}
==About this Structure==
==About this Structure==
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[[Category: Gamma crystallin s]]
[[Category: Gamma crystallin s]]
[[Category: Multigene family]]
[[Category: Multigene family]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:55:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:18:33 2008''

Revision as of 13:18, 30 June 2008

Image:1a7h.png

Template:STRUCTURE 1a7h

GAMMA S CRYSTALLIN C-TERMINAL DOMAIN

Template:ABSTRACT PUBMED 9681865

About this Structure

1A7H is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

The C-terminal domains of gammaS-crystallin pair about a distorted twofold axis., Basak AK, Kroone RC, Lubsen NH, Naylor CE, Jaenicke R, Slingsby C, Protein Eng. 1998 May;11(5):337-44. PMID:9681865

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