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== Function ==
== Function ==
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The protein is a complex composed of the [[ poly (ADP-ribose) glycohydrolase]] (PARG) and anthraquinone PDD00013907. The post-translational modifications of the PAR protein (poly ADP-ribose) are important for DNA stability. The PARG is used for one of these modifications, the hydrolyzation of specific ribose-ribose bonds present in PAR which leads to the degradation of PAR.
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The protein is a complex composed of the [[ poly (ADP-ribose) glycohydrolase]] (PARG) and anthraquinone PDD00013907. The post-translational modifications of the PAR protein (poly ADP-ribose) are important for DNA stability.
PDD00013907 is an anthraquinone which is a polycyclic aromatic hydrocarbon usually used in biopesticides as a pest repellant. Here it is considered as a free ligand (of identification number on PDB: 7JB) that can bind to the PARG creating the protein complex 6HMM.
PDD00013907 is an anthraquinone which is a polycyclic aromatic hydrocarbon usually used in biopesticides as a pest repellant. Here it is considered as a free ligand (of identification number on PDB: 7JB) that can bind to the PARG creating the protein complex 6HMM.
=== Post-translational modifications to stabilize DNA ===
=== Post-translational modifications to stabilize DNA ===
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There are several possible post-translational modifications to stabilize DNA. Most commonly they would be phosphorylation, acetylation or methylation <ref>PMID: 21037856</ref>. Another post-translational modification concerning the 6HMM protein is made on the PAR protein. The PARG is used for one of these modifications, the hydrolyzation of specific ribose-ribose bonds present in PAR which leads to the degradation of PAR.
=== The mechanism of the post-translational modifications ===
=== The mechanism of the post-translational modifications ===

Revision as of 16:54, 29 December 2019

This Sandbox is Reserved from 25/11/2019, through 30/9/2020 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1091 through Sandbox Reserved 1115.
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6HMM protein

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References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
  3. ↑ Oberle C, Blattner C. Regulation of the DNA Damage Response to DSBs by Post-Translational Modifications. Curr Genomics. 2010 May;11(3):184-98. doi: 10.2174/138920210791110979. PMID:21037856 doi:http://dx.doi.org/10.2174/138920210791110979
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