1a7m

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{{STRUCTURE_1a7m| PDB=1a7m | SCENE= }}
{{STRUCTURE_1a7m| PDB=1a7m | SCENE= }}
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'''LEUKAEMIA INHIBITORY FACTOR CHIMERA (MH35-LIF), NMR, 20 STRUCTURES'''
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===LEUKAEMIA INHIBITORY FACTOR CHIMERA (MH35-LIF), NMR, 20 STRUCTURES===
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==Overview==
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The solution structure of a murine-human chimera of leukemia inhibitory factor (LIF), a 180-residue cytokine with a molecular mass of 20 kDa, has been determined using multidimensional heteronuclear NMR techniques. The protein contains four alpha-helices, the relative orientations of which are well defined on the basis of long-range interhelical nuclear Overhauser effects. The helices are arranged in an up-up-down-down orientation, as found in other four-helix bundle cytokines, and the overall topology of the chimera is similar to that of the crystal structure of murine LIF (Robinson, R. C., Grey, L. M., Staunton, D., Vankelecom, H. Vernallis, A. B., Moreau, J. F., Stuart, D. I., Heath, J. K., and Jones, E. Y. (1994) Cell 77, 1101-1116). Differences between the structures are evident in the N-terminal region, where the peptide bond preceding Pro17 has a trans-conformation in solution but a cis-conformation in the crystal, and in the small antiparallel beta-sheet encompassing residues in the N terminus and the CD loop in the crystal structure, which is not apparent in solution. There are also minor differences in the extent of the helices. Other than at the N terminus, the main difference between the two structures occurs at the C-terminal end of the CD loop. As this loop is close to a receptor-binding site on LIF that makes a major contribution to high affinity binding to the LIF receptor alpha-chain, these differences between the solution and crystal structures should be taken into account in structural models of LIF receptor interactions.
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(as it appears on PubMed at http://www.pubmed.gov), where 9593715 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9593715}}
==About this Structure==
==About this Structure==
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1A7M is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A7M OCA].
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1A7M is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A7M OCA].
==Reference==
==Reference==
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[[Category: Cytokine]]
[[Category: Cytokine]]
[[Category: Four helical bundle]]
[[Category: Four helical bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:56:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:19:05 2008''

Revision as of 13:19, 30 June 2008

Image:1a7m.png

Template:STRUCTURE 1a7m

LEUKAEMIA INHIBITORY FACTOR CHIMERA (MH35-LIF), NMR, 20 STRUCTURES

Template:ABSTRACT PUBMED 9593715

About this Structure

1A7M is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

Solution structure of leukemia inhibitory factor., Hinds MG, Maurer T, Zhang JG, Nicola NA, Norton RS, J Biol Chem. 1998 May 29;273(22):13738-45. PMID:9593715

Page seeded by OCA on Mon Jun 30 16:19:05 2008

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