6tsk

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m (Protected "6tsk" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6tsk is ON HOLD
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==Beta-galactosidase in complex with L-ribose==
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<StructureSection load='6tsk' size='340' side='right'caption='[[6tsk]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6tsk]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TSK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TSK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0MK:L-RIBOPYRANOSE'>0MK</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tsk OCA], [http://pdbe.org/6tsk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tsk RCSB], [http://www.ebi.ac.uk/pdbsum/6tsk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tsk ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Recent advances in cryo-electron microscopy (EM) structure determination have pushed the resolutions obtainable by the method into the range widely considered to be of utility for drug discovery. Here, we review the use of cryo-EM in fragment-based drug discovery (FBDD) based on in-house method development. We demonstrate not only that cryo-EM can reveal details of the molecular interactions between fragments and a protein, but also that the current reproducibility, quality, and throughput are compatible with FBDD. We exemplify this using the test system beta-galactosidase (Bgal) and the oncology target pyruvate kinase 2 (PKM2).
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Authors:
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Fragment-based drug discovery using cryo-EM.,Saur M, Hartshorn MJ, Dong J, Reeks J, Bunkoczi G, Jhoti H, Williams PA Drug Discov Today. 2019 Dec 23. pii: S1359-6446(19)30465-9. doi:, 10.1016/j.drudis.2019.12.006. PMID:31877353<ref>PMID:31877353</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 6tsk" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Bunkoczi, G]]
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[[Category: Dong, J]]
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[[Category: Hartshorn, M J]]
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[[Category: Jhoti, H]]
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[[Category: Reeks, J]]
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[[Category: Saur, M]]
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[[Category: Williams, P A]]
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[[Category: Bgal]]
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[[Category: L-ribose]]
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[[Category: Sugar binding protein]]

Revision as of 07:42, 8 January 2020

Beta-galactosidase in complex with L-ribose

PDB ID 6tsk

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