6vdb
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==SETD2 in complex with a H3-variant peptide== | |
| - | + | <StructureSection load='6vdb' size='340' side='right'caption='[[6vdb]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6vdb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VDB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6vdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vdb OCA], [http://pdbe.org/6vdb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vdb RCSB], [http://www.ebi.ac.uk/pdbsum/6vdb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vdb ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SETD2_HUMAN SETD2_HUMAN]] Histone methyltransferase that methylates 'Lys-36' of histone H3. H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation. Probably plays a role in chromatin structure modulation during elongation via its interaction with hyperphosphorylated POLR2A. Binds DNA at promoters. May also act as a transcription activator that binds to promoters. Binds to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression.<ref>PMID:16118227</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Beldar, S]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Edwards, A M]] | ||
| + | [[Category: Jeltsch, A]] | ||
| + | [[Category: Min, J]] | ||
| + | [[Category: Tempel, W]] | ||
| + | [[Category: Sgc]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 15:47, 29 January 2020
SETD2 in complex with a H3-variant peptide
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