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6pyz

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Current revision (07:38, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6pyz' size='340' side='right'caption='[[6pyz]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
<StructureSection load='6pyz' size='340' side='right'caption='[[6pyz]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6pyz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PYZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PYZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6pyz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PYZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PYZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=H7S:(3S)-3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione'>H7S</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ZIQ:alpha-methyl-L-tryptophan'>ZIQ</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.02&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6pyy|6pyy]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H7S:(3S)-3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione'>H7S</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ZIQ:alpha-methyl-L-tryptophan'>ZIQ</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_2,3-dioxygenase Tryptophan 2,3-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.11 1.13.11.11] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pyz OCA], [https://pdbe.org/6pyz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pyz RCSB], [https://www.ebi.ac.uk/pdbsum/6pyz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pyz ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pyz OCA], [http://pdbe.org/6pyz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pyz RCSB], [http://www.ebi.ac.uk/pdbsum/6pyz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pyz ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/T23O_HUMAN T23O_HUMAN]] Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity).
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[https://www.uniprot.org/uniprot/T23O_HUMAN T23O_HUMAN] Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6pyz" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6pyz" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Tryptophan 2,3-dioxygenase]]
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[[Category: Lewis-Ballester A]]
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[[Category: Lewis-Ballester, A]]
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[[Category: Pham KN]]
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[[Category: Pham, K N]]
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[[Category: Yeh SR]]
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[[Category: Yeh, S R]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Pf-06840003]]
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[[Category: Tryptophan dioxygenase]]
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Current revision

Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PF-06840003 in Active Site

PDB ID 6pyz

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