6u6v
From Proteopedia
(Difference between revisions)
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<StructureSection load='6u6v' size='340' side='right'caption='[[6u6v]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='6u6v' size='340' side='right'caption='[[6u6v]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6u6v]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U6V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U6V FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6u6v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U6V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U6V FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VSIR, C10orf54, SISP1, VISTA, PP2135, UNQ730/PRO1412 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u6v OCA], [http://pdbe.org/6u6v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u6v RCSB], [http://www.ebi.ac.uk/pdbsum/6u6v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u6v ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u6v OCA], [http://pdbe.org/6u6v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u6v RCSB], [http://www.ebi.ac.uk/pdbsum/6u6v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u6v ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/VISTA_HUMAN VISTA_HUMAN]] Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777).[UniProtKB:Q9D659]<ref>PMID:20666777</ref> <ref>PMID:24691993</ref> | [[http://www.uniprot.org/uniprot/VISTA_HUMAN VISTA_HUMAN]] Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777).[UniProtKB:Q9D659]<ref>PMID:20666777</ref> <ref>PMID:24691993</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Programmed death-1 homolog (PD-1H), a CD28/B7 family molecule, coinhibits T cell activation and is an attractive immunotherapeutic target for cancer and inflammatory diseases. The molecular basis of its function, however, is unknown. Bioinformatic analyses indicated that PD-1H has a very long Ig variable region (IgV)-like domain and extraordinarily high histidine content, suggesting that unique structural features may contribute to coinhibitory mechanisms. Here we present the 1.9-A crystal structure of the human PD-1H extracellular domain. It reveals an elongated CC' loop and a striking concentration of histidine residues, located in the complementarity-determining region-like proximal half of the molecule. We show that surface-exposed histidine clusters are essential for robust inhibition of T cell activation. PD-1H exhibits a noncanonical IgV-like topology including an extra "H" beta-strand and "clamping" disulfide, absent in known IgV-like structures, that likely restricts its orientation on the cell surface differently from other IgV-like domains. These results provide important insight into a molecular basis of T cell coinhibition by PD-1H. | ||
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| + | Structural insight into T cell coinhibition by PD-1H (VISTA).,Slater BT, Han X, Chen L, Xiong Y Proc Natl Acad Sci U S A. 2020 Jan 9. pii: 1908711117. doi:, 10.1073/pnas.1908711117. PMID:31919279<ref>PMID:31919279</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6u6v" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chen, L]] | [[Category: Chen, L]] | ||
Revision as of 16:55, 22 January 2020
Crystal structure of human PD-1H / VISTA
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