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3wsz

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<StructureSection load='3wsz' size='340' side='right'caption='[[3wsz]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='3wsz' size='340' side='right'caption='[[3wsz]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3wsz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WSZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WSZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3wsz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WSZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WSZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wsx|3wsx]], [[3wsy|3wsy]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3wsx|3wsx]], [[3wsy|3wsy]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SORL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SORL1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wsz OCA], [http://pdbe.org/3wsz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wsz RCSB], [http://www.ebi.ac.uk/pdbsum/3wsz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wsz ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wsz OCA], [https://pdbe.org/3wsz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wsz RCSB], [https://www.ebi.ac.uk/pdbsum/3wsz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wsz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SORL_HUMAN SORL_HUMAN]] Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction.
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[[https://www.uniprot.org/uniprot/SORL_HUMAN SORL_HUMAN]] Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction.
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Revision as of 05:30, 10 August 2022

SorLA Vps10p domain in complex with Abeta-derived peptide

PDB ID 3wsz

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