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4m4s

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<StructureSection load='4m4s' size='340' side='right'caption='[[4m4s]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
<StructureSection load='4m4s' size='340' side='right'caption='[[4m4s]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4m4s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sacs2 Sacs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M4S FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4m4s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus_P2 Saccharolobus solfataricus P2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M4S FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4m0l|4m0l]], [[4m2l|4m2l]], [[4m53|4m53]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m4s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m4s OCA], [https://pdbe.org/4m4s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m4s RCSB], [https://www.ebi.ac.uk/pdbsum/4m4s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m4s ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">eif2g ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=273057 SACS2])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m4s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m4s OCA], [http://pdbe.org/4m4s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4m4s RCSB], [http://www.ebi.ac.uk/pdbsum/4m4s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4m4s ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IF2G_SULSO IF2G_SULSO]] eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (By similarity).
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[https://www.uniprot.org/uniprot/IF2G_SACS2 IF2G_SACS2] eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.[HAMAP-Rule:MF_00119]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Sacs2]]
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[[Category: Saccharolobus solfataricus P2]]
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[[Category: Arkhipova, V I]]
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[[Category: Arkhipova VI]]
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[[Category: Gabdulkhakov, A G]]
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[[Category: Gabdulkhakov AG]]
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[[Category: Garber, M B]]
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[[Category: Garber MB]]
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[[Category: Nikonov, O S]]
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[[Category: Nikonov OS]]
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[[Category: Nikonov, S V]]
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[[Category: Nikonov SV]]
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[[Category: Nikulin, A D]]
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[[Category: Nikulin AD]]
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[[Category: Stolboushkina, E A]]
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[[Category: Stolboushkina EA]]
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[[Category: Aif2]]
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[[Category: Aif2 gamma subunit]]
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[[Category: G-protein]]
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[[Category: Gtp-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: Protein biosynthesis]]
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[[Category: Rna-binding]]
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[[Category: Translation]]
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[[Category: Translation initiation]]
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Revision as of 10:55, 21 December 2022

Gamma subunit of the translation initiation factor 2 from Sulfolobus solfataricus in complex with GDP and formate ion mimic aIF2gamma*GDP*Pi complex (a formate ion substitutes for Pi)

PDB ID 4m4s

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