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4q0m

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<StructureSection load='4q0m' size='340' side='right'caption='[[4q0m]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
<StructureSection load='4q0m' size='340' side='right'caption='[[4q0m]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4q0m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrfu Pyrfu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q0M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q0M FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4q0m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus_DSM_3638 Pyrococcus furiosus DSM 3638]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q0M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q0M FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4CS:(4S)-2-METHYL-1,4,5,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>4CS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4CS:(4S)-2-METHYL-1,4,5,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>4CS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PF2047, ph0066 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=186497 PYRFU])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q0m OCA], [https://pdbe.org/4q0m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q0m RCSB], [https://www.ebi.ac.uk/pdbsum/4q0m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q0m ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Asparaginase Asparaginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.1 3.5.1.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q0m OCA], [http://pdbe.org/4q0m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q0m RCSB], [http://www.ebi.ac.uk/pdbsum/4q0m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q0m ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ASPG_PYRFU ASPG_PYRFU] Catalyzes the hydrolysis of L-asparagine into L-aspartate and ammonia. Displays no glutaminase activity, a highly desirable therapeutic property.<ref>PMID:20370616</ref> <ref>PMID:22166247</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Asparaginase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Pyrfu]]
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[[Category: Pyrococcus furiosus DSM 3638]]
[[Category: Ashish]]
[[Category: Ashish]]
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[[Category: Kundu, B]]
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[[Category: Kundu B]]
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[[Category: Sharma, P]]
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[[Category: Sharma P]]
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[[Category: Singh, S]]
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[[Category: Singh S]]
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[[Category: Tomar, R]]
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[[Category: Tomar R]]
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[[Category: Yadav, S P.S]]
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[[Category: Yadav SPS]]
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[[Category: Hydrolase]]
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Revision as of 07:39, 8 February 2023

Crystal structure of Pyrococcus furiosus L-asparaginase

PDB ID 4q0m

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