5urs

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Current revision (13:33, 4 October 2023) (edit) (undo)
 
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<StructureSection load='5urs' size='340' side='right'caption='[[5urs]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
<StructureSection load='5urs' size='340' side='right'caption='[[5urs]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5urs]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5URS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5URS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5urs]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5URS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5URS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8LA:N-[4-CHLORO-3-(ALPHA-D-RIBOFURANOSYLOXY)PHENYL]-N-{2-[3-(PROP-1-EN-2-YL)PHENYL]PROPAN-2-YL}UREA'>8LA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.388&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4myx|4myx]], [[4my8|4my8]], [[4my1|4my1]], [[4qm1|4qm1]], [[4mya|4mya]], [[4my9|4my9]], [[4mjm|4mjm]], [[3tsd|3tsd]], [[3usb|3usb]], [[3tsb|3tsb]], [[5urr|5urr]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8LA:N-[4-CHLORO-3-(ALPHA-D-RIBOFURANOSYLOXY)PHENYL]-N-{2-[3-(PROP-1-EN-2-YL)PHENYL]PROPAN-2-YL}UREA'>8LA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">guaB, GBAA_0008, A8C77_00065, ABW01_29210 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 "Bacillus cereus var. anthracis" (Cohn 1872) Smith et al. 1946])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5urs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5urs OCA], [https://pdbe.org/5urs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5urs RCSB], [https://www.ebi.ac.uk/pdbsum/5urs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5urs ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5urs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5urs OCA], [http://pdbe.org/5urs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5urs RCSB], [http://www.ebi.ac.uk/pdbsum/5urs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5urs ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q81W29_BACAN Q81W29_BACAN]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).[HAMAP-Rule:MF_01964]
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[https://www.uniprot.org/uniprot/A0A6L8P2U9_BACAN A0A6L8P2U9_BACAN] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964]
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: IMP dehydrogenase]]
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[[Category: Bacillus anthracis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Anderson, W F]]
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[[Category: Anderson WF]]
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[[Category: Structural genomic]]
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[[Category: Gollapalli D]]
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[[Category: Gollapalli, D]]
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[[Category: Gu M]]
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[[Category: Gu, M]]
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[[Category: Hedstrom L]]
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[[Category: Hedstrom, L]]
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[[Category: Joachimiak A]]
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[[Category: Joachimiak, A]]
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[[Category: Kim Y]]
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[[Category: Kim, Y]]
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[[Category: Makowska-Grzyska M]]
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[[Category: Makowska-Grzyska, M]]
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[[Category: Maltseva N]]
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[[Category: Maltseva, N]]
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[[Category: Csgid]]
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[[Category: Delta cb]]
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[[Category: Impdh]]
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[[Category: Oxidoreductase]]
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[[Category: Tim barrel]]
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Current revision

Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Bacillus anthracis in the complex with IMP and the inhibitor P178

PDB ID 5urs

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