This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5wjq

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:15, 4 October 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='5wjq' size='340' side='right'caption='[[5wjq]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
<StructureSection load='5wjq' size='340' side='right'caption='[[5wjq]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5wjq]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WJQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WJQ FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5wjq]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WJQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WJQ FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.794&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Znf568, chato, Zfp568 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wjq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wjq OCA], [http://pdbe.org/5wjq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wjq RCSB], [http://www.ebi.ac.uk/pdbsum/5wjq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wjq ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wjq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wjq OCA], [https://pdbe.org/5wjq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wjq RCSB], [https://www.ebi.ac.uk/pdbsum/5wjq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wjq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/ZN568_MOUSE ZN568_MOUSE]] Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction (PubMed:22110054, PubMed:27658112). Essential during embryonic development, where it acts as direct repressor of IGF2-P0, placental-specific transcript of IGF2, in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers (PubMed:18701545, PubMed:22110054, PubMed:28522536). Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta (PubMed:18701545, PubMed:21094155). May enhance proliferation or maintenance of neural stem cells (PubMed:23071813).<ref>PMID:18701545</ref> <ref>PMID:21094155</ref> <ref>PMID:22110054</ref> <ref>PMID:23071813</ref> <ref>PMID:27658112</ref>
+
[https://www.uniprot.org/uniprot/ZN568_MOUSE ZN568_MOUSE] Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction (PubMed:22110054, PubMed:27658112). Essential during embryonic development, where it acts as direct repressor of IGF2-P0, placental-specific transcript of IGF2, in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers (PubMed:18701545, PubMed:22110054, PubMed:28522536). Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta (PubMed:18701545, PubMed:21094155). May enhance proliferation or maintenance of neural stem cells (PubMed:23071813).<ref>PMID:18701545</ref> <ref>PMID:21094155</ref> <ref>PMID:22110054</ref> <ref>PMID:23071813</ref> <ref>PMID:27658112</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 24: Line 24:
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Lk3 transgenic mice]]
+
[[Category: Mus musculus]]
-
[[Category: Cheng, X]]
+
[[Category: Cheng X]]
-
[[Category: Patel, A]]
+
[[Category: Patel A]]
-
[[Category: C2h2 type zinc finger]]
+
-
[[Category: Dna binding]]
+
-
[[Category: Gene regulation]]
+
-
[[Category: Gene regulation-dna complex]]
+
-
[[Category: Transferase-dna complex]]
+

Current revision

mouseZFP568-ZnF2-11 in complex with DNA

PDB ID 5wjq

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5wjq"
Personal tools