5x45

<table><tr><td colspan='2'>[[5x45]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_rhinovirus_c Human rhinovirus c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X45 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X45 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x45 OCA], [http://pdbe.org/5x45 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x45 RCSB], [http://www.ebi.ac.uk/pdbsum/5x45 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x45 ProSAT]</span></td></tr>

<div style="background-color:#fffaf0;">

== Publication Abstract from PubMed ==

The majority of outbreaks of the common cold are caused by rhinoviruses. The 2A protease (2A(pro)) of human rhinoviruses (HRVs) is known to play important roles in the propagation of the virus and the modulation of host signal pathways to facilitate viral replication. The 2A(pro) from human rhinovirus C15 (HRV-C15) has been expressed in Escherichia coli and purified by affinity chromatography, ion-exchange chromatography and gel-filtration chromatography. The crystals diffracted to 2.6 A resolution. The structure was solved by molecular replacement using the structure of 2A(pro) from coxsackievirus A16 (CVA16) as the search model. The structure contains a conserved His-Asp-Cys catalytic triad and a Zn(2+)-binding site. Comparison with other 2A(pro) structures from enteroviruses reveals that the substrate-binding cleft of 2A(pro) from HRV-C15 exhibits a more open conformation, which presumably favours substrate binding.

 

<div class="pdbe-citations 5x45" style="background-color:#fffaf0;"></div>

== References ==

[[Category: Human rhinovirus c]]

[[Category: Ling, H]]

[[Category: Shaw, N]]

[[Category: Sun, Y]]

[[Category: Wang, X]]

[[Category: Yang, P]]

[[Category: Viral protein]]