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6csl

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Current revision (14:30, 13 March 2024) (edit) (undo)
 
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<StructureSection load='6csl' size='340' side='right'caption='[[6csl]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
<StructureSection load='6csl' size='340' side='right'caption='[[6csl]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6csl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CSL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CSL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6csl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CSL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.921&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">phtD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6csl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6csl OCA], [http://pdbe.org/6csl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6csl RCSB], [http://www.ebi.ac.uk/pdbsum/6csl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6csl ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6csl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6csl OCA], [https://pdbe.org/6csl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6csl RCSB], [https://www.ebi.ac.uk/pdbsum/6csl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6csl ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q8DQ08_STRR6 Q8DQ08_STRR6]
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The bacterium Streptococcus pneumoniae (the pneumococcus) is a major human pathogen that requires Zn(2+) for its survival and virulence in the host environment. Polyhistidine triad protein D (PhtD) has a known role in pneumococcal Zn(2+) homeostasis. However, the mechanistic basis of PhtD function remains unclear, partly due to a lack of structural information. Here, we determined the crystal structure of the fragment PhtD(269-339) , containing the third Zn(2+) -binding histidine triad (HT) motif of the protein. Analysis of the structure suggests that Zn(2+) -binding occurs at the surface of the protein and that all five HT motifs in the protein bind Zn(2+) and share similar structures. These new structural insights aid in our understanding of how the Pht proteins facilitate pneumococcal Zn(2+) acquisition. This article is protected by copyright. All rights reserved.
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Structural characterisation of the HT3 motif of the polyhistidine triad protein D from Streptococcus pneumoniae.,Luo Z, Pederick VG, Paton JC, McDevitt CA, Kobe B FEBS Lett. 2018 Jun 1. doi: 10.1002/1873-3468.13122. PMID:29856892<ref>PMID:29856892</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6csl" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Kobe, B]]
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[[Category: Streptococcus pneumoniae]]
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[[Category: Luo, Z]]
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[[Category: Kobe B]]
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[[Category: McDevitt, C A]]
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[[Category: Luo Z]]
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[[Category: Paton, J C]]
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[[Category: McDevitt CA]]
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[[Category: Pederick, V G]]
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[[Category: Paton JC]]
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[[Category: Metal binding protein]]
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[[Category: Pederick VG]]
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[[Category: Polyhistidine triad]]
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[[Category: Zinc homeostasis]]
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Current revision

Pneumococcal PhtD protein 269-339 fragment with bound Zn(II)

PDB ID 6csl

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