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6nih

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Current revision (06:54, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6nih' size='340' side='right'caption='[[6nih]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='6nih' size='340' side='right'caption='[[6nih]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6nih]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bdellostoma_stoutii Bdellostoma stoutii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NIH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NIH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6nih]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Eptatretus_stoutii Eptatretus stoutii] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NIH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VLRB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7765 Bdellostoma stoutii])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900017:triacetyl-beta-chitotriose'>PRD_900017</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nih OCA], [http://pdbe.org/6nih PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nih RCSB], [http://www.ebi.ac.uk/pdbsum/6nih PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nih ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nih OCA], [https://pdbe.org/6nih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nih RCSB], [https://www.ebi.ac.uk/pdbsum/6nih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nih ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TLR1_HUMAN TLR1_HUMAN]] Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
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[https://www.uniprot.org/uniprot/Q2YDZ3_EPTST Q2YDZ3_EPTST] [https://www.uniprot.org/uniprot/TLR1_HUMAN TLR1_HUMAN] Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6nih" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6nih" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
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*[[Variable lymphocyte receptor 3D structures|Variable lymphocyte receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bdellostoma stoutii]]
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[[Category: Eptatretus stoutii]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Su, L]]
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[[Category: Su L]]
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[[Category: Zhang, H]]
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[[Category: Zhang H]]
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[[Category: Immune system]]
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[[Category: Toll-like receptor]]
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Current revision

Crystal structure of human TLR1

PDB ID 6nih

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