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1a8y

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[[Image:1a8y.gif|left|200px]]
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{{Seed}}
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[[Image:1a8y.png|left|200px]]
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{{STRUCTURE_1a8y| PDB=1a8y | SCENE= }}
{{STRUCTURE_1a8y| PDB=1a8y | SCENE= }}
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'''CRYSTAL STRUCTURE OF CALSEQUESTRIN FROM RABBIT SKELETAL MUSCLE SARCOPLASMIC RETICULUM AT 2.4 A RESOLUTION'''
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===CRYSTAL STRUCTURE OF CALSEQUESTRIN FROM RABBIT SKELETAL MUSCLE SARCOPLASMIC RETICULUM AT 2.4 A RESOLUTION===
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==Overview==
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Calsequestrin, the major Ca2+ storage protein of muscle, coordinately binds and releases 40-50 Ca2+ ions per molecule for each contraction-relaxation cycle by an uncertain mechanism. We have determined the structure of rabbit skeletal muscle calsequestrin. Three very negative thioredoxin-like domains surround a hydrophilic center. Each monomer makes two extensive dimerization contacts, both of which involve the approach of many negative groups. This structure suggests a mechanism by which calsequestrin may achieve high capacity Ca2+ binding. The suggested mechanism involves Ca2+-induced collapse of the three domains and polymerization of calsequestrin monomers arising from three factors: N-terminal arm exchange, helix-helix contacts and Ca2+ cross bridges. This proposed structure-based mechanism accounts for the observed coupling of high capacity Ca2+ binding with protein precipitation.
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The line below this paragraph, {{ABSTRACT_PUBMED_9628486}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9628486 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9628486}}
==About this Structure==
==About this Structure==
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[[Category: Rabbit skeletal muscle]]
[[Category: Rabbit skeletal muscle]]
[[Category: Sarcoplasmic reticulum]]
[[Category: Sarcoplasmic reticulum]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:59:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:24:04 2008''

Revision as of 13:24, 30 June 2008

Image:1a8y.png

Template:STRUCTURE 1a8y

CRYSTAL STRUCTURE OF CALSEQUESTRIN FROM RABBIT SKELETAL MUSCLE SARCOPLASMIC RETICULUM AT 2.4 A RESOLUTION

Template:ABSTRACT PUBMED 9628486

About this Structure

1A8Y is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of calsequestrin from rabbit skeletal muscle sarcoplasmic reticulum., Wang S, Trumble WR, Liao H, Wesson CR, Dunker AK, Kang CH, Nat Struct Biol. 1998 Jun;5(6):476-83. PMID:9628486

Page seeded by OCA on Mon Jun 30 16:24:04 2008

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