Sandbox Reserved 1606
From Proteopedia
(Difference between revisions)
(New page: {{Sandbox_Reserved_CH462_Biochemistry_II}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> ==Your Heading Here (maybe something like 'Structure')== <StructureSection load='1stp' size='340' side...) |
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{{Sandbox_Reserved_CH462_Biochemistry_II}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | {{Sandbox_Reserved_CH462_Biochemistry_II}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
| - | == | + | ==ABCG2 Multidrug Transporter== |
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
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| - | + | ==Introduction== | |
| + | The [https://en.wikipedia.org/wiki/ABCG2 ABCG2 multidrug transporter] is part of the ATP-binding cassette (ABC) transporter family. Also know as the breast cancer resistance protein (BCRP), ABCG2 has physiological roles in various tissue cells including the mammary gland and the blood-brain, bloodtestis, and maternal-fetal barriers.<ref name="Taylor"/> | ||
== Function == | == Function == | ||
| + | Transports xenobiotic molecules out of the cell (molecules that shouldn't be there) to protect cellular tissue | ||
| - | == | + | == Structural highlights == |
| + | ===ATP Bound and Unbound Conformations=== | ||
| - | + | [[Image:Example.jpg]] | |
| - | == | + | ===Cavities and Lysine Plug=== |
| + | |||
| + | ==Disease== | ||
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| + | ===Cancer=== | ||
| + | ABCG2 contributes to [https://en.wikipedia.org/wiki/Multiple_drug_resistance multidrug resistance] in cancer cells by exporting anti-tumor drugs out of cells which is an obstacle in cancer treatment.<ref name="Taylor"/> | ||
| + | brief description of the cancer genes listed in the papers (papers talk about how some cancers had more expression of abcg2 genes) | ||
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| + | |||
| + | ===ABCG2 as a Target for Inhibition=== | ||
| + | Talk about how and why it would be a good target for the treatment of cancer | ||
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
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</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
| + | <ref name="Taylor">PMID:28554189</ref> | ||
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<references/> | <references/> | ||
| + | ==Student Contributors=== | ||
Revision as of 19:55, 23 March 2020
| This Sandbox is Reserved from Jan 13 through September 1, 2020 for use in the course CH462 Biochemistry II taught by R. Jeremy Johnson at the Butler University, Indianapolis, USA. This reservation includes Sandbox Reserved 1598 through Sandbox Reserved 1627. |
To get started:
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ABCG2 Multidrug Transporter
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References
- ↑ 1.0 1.1 1.2 Taylor NMI, Manolaridis I, Jackson SM, Kowal J, Stahlberg H, Locher KP. Structure of the human multidrug transporter ABCG2. Nature. 2017 Jun 22;546(7659):504-509. doi: 10.1038/nature22345. Epub 2017 May, 29. PMID:28554189 doi:http://dx.doi.org/10.1038/nature22345
