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1a9i

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[[Image:1a9i.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1a9i| PDB=1a9i | SCENE= }}
{{STRUCTURE_1a9i| PDB=1a9i | SCENE= }}
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'''APYRIMIDINIC DNA WITH BOUND WATER AT THE DAMAGED SITE, ALPHA FORM, NMR, 1 STRUCTURE'''
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===APYRIMIDINIC DNA WITH BOUND WATER AT THE DAMAGED SITE, ALPHA FORM, NMR, 1 STRUCTURE===
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==Overview==
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Natural and exogenous processes can give rise to abasic sites with either a purine or pyrimidine as the base on the opposing strand. The solution state structures of the apyrimidinic DNA duplex, with D6 indicating an abasic site, [sequence: see text] referred to as AD, and the apurinic DNA duplex with a dC17, referred to as CD, have been determined. A particularly striking difference is that the abasic site in CD is predominantly a beta hemiacetal, whereas in AD the alpha and beta forms are equally present. Hydrogen bonding with water by the abasic site and the base on the opposite strand appears to play a large role in determining the structure near the damaged site. Comparison of these structures with that of a duplex DNA containing a thymine glycol at the same position as the abasic site and with that of a duplex DNA containing an abasic site in the middle of a curved DNA sequence offers some insight into the common and distinct structural features of damaged DNA sites.
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The line below this paragraph, {{ABSTRACT_PUBMED_9624147}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9624147 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9624147}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A9I OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A9I OCA].
==Reference==
==Reference==
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[[Category: Damaged dna]]
[[Category: Damaged dna]]
[[Category: Water]]
[[Category: Water]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:00:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:26:07 2008''

Revision as of 13:26, 30 June 2008

Image:1a9i.png

Template:STRUCTURE 1a9i

APYRIMIDINIC DNA WITH BOUND WATER AT THE DAMAGED SITE, ALPHA FORM, NMR, 1 STRUCTURE

Template:ABSTRACT PUBMED 9624147

About this Structure

Full experimental information is available from OCA.

Reference

Structures of apurinic and apyrimidinic sites in duplex DNAs., Beger RD, Bolton PH, J Biol Chem. 1998 Jun 19;273(25):15565-73. PMID:9624147

Page seeded by OCA on Mon Jun 30 16:26:07 2008

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